Environ Health Perspect. 1991 Dec;96:199-202. doi: 10.1289/ehp.9196199.
Cage allocation designs for rodent carcinogenicity experiments are discussed and presented with the goal of avoiding dosage group biases related to cage location. Considerations in selecting a cage design are first discussed in general terms. Specific designs are presented for use in experiments involving three, four, and five dose groups and with one, four, and five rodents per cage. Priorities for balancing treatment groups include horizontal position on shelf and shelf of rack, nearest neighbor balance, and male-female balance. It is proposed that these balance criteria be considered together with practical issues, such as the ability to accurately conform to a design and to determine a sensible and efficient design for each experiment.
啮齿动物致癌性实验的笼位分配设计的讨论与展示，旨在避免与笼位相关的剂量组偏差。首先以一般术语讨论选择笼设计的注意事项。为涉及三个、四个和五个剂量组以及每个笼中一个、四个和五个啮齿动物的实验提供了具体设计。平衡处理组的优先级包括搁板上的水平位置和架子的搁板、最近邻平衡和雌雄平衡。建议将这些平衡标准与实际问题一起考虑，例如准确符合设计的能力以及为每个实验确定合理有效的设计的能力。
