Gushchin D Iu, Ebralidze K K, Mirzabekov A D
Mol Biol (Mosk). 1991 Sep-Oct;25(5):1400-11.
Histones' H2A and H2B peptidic points which interact with nucleosomal DNA have been identified by using the methods of DNA--protein covalent cross-linking. H2B can be linked to DNA via its N-terminal tail and via several lysines contained within residues 24-34. The most prominent site of histone H2A covalent linking to DNA is His-123, the less prominent being Lys-119 and Lys-124.
通过DNA-蛋白质共价交联方法已鉴定出组蛋白H2A和H2B与核小体DNA相互作用的肽段位点。H2B可通过其N端尾巴以及24-34位残基内所含的几个赖氨酸与DNA相连。组蛋白H2A与DNA共价连接的最显著位点是His-123,较不显著的是Lys-119和Lys-124。