Shaw Greg L, Patel Hiten Rh
University College Hospital, Institute of Urology, Euston Road, London, UK.
Expert Opin Drug Metab Toxicol. 2007 Jun;3(3):435-9. doi: 10.1517/17425255.3.3.435.
Overactive bladder is a common and disabling problem. The mainstay of pharmacological treatment is with oral anticholinergic drugs. Anticholinergic side effects are common and include dry mouth and constipation. Compliance is limited by these side effects. Transdermal administration of oxybutynin has been shown to be as effective as oral treatment while minimising the anticholinergic side effects. Skin reactions occur frequently, necessitating changes of application site. Despite this, the preparation is a useful element in the armamentarium to treat overactive bladder. It is likely to be particularly useful in those in whom side effects of oral medication are intolerable or in whom oral administration of drug is not possible. Here, the pharmacokinetics, pharmacodynamics, efficacy and safety of transdermal oxybutynin are reviewed.
膀胱过度活动症是一种常见且使人致残的病症。药物治疗的主要手段是口服抗胆碱能药物。抗胆碱能副作用很常见，包括口干和便秘。这些副作用限制了患者的依从性。已证明经皮给予奥昔布宁与口服治疗效果相同，同时能将抗胆碱能副作用降至最低。皮肤反应频繁发生，需要更换用药部位。尽管如此，该制剂仍是治疗膀胱过度活动症的有效药物之一。它可能对那些无法耐受口服药物副作用或无法口服给药的患者特别有用。在此，对经皮奥昔布宁的药代动力学、药效学、疗效和安全性进行综述。
