Alzoghaibi Mohammed A, Bahammam Ahmed S
Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Respirology. 2007 May;12(3):439-42. doi: 10.1111/j.1440-1843.2007.01034.x.
The effect of inhaled steroids on oxidative stress in asthmatics is unclear. The levels of lipid peroxides in the serum of asthmatic patients, whose symptoms were controlled with inhaled corticosteroids and long-acting beta(2)-agonists, were measured in this study.
Twenty asthmatic patients and 17 matched, healthy controls were recruited. Oxidative stress levels were quantified by measuring thiobarbituric acid reactive substances.
After 3 months of treatment, the mean lipid peroxide concentrations were significantly higher in asthmatic patients than in the healthy controls (4.2 +/- 0.13 micromol/mL vs. 3.6 +/- 0.07 micromol/mL, respectively).
The level of lipid peroxides is higher in patients with asthma than in healthy controls, even when the asthma is well controlled after 3 months of treatment. A longer period of therapy may be required before lipid peroxidation normalizes.
吸入性类固醇对哮喘患者氧化应激的影响尚不清楚。本研究测定了使用吸入性糖皮质激素和长效β2受体激动剂控制症状的哮喘患者血清中脂质过氧化物的水平。
招募了20名哮喘患者和17名匹配的健康对照者。通过测量硫代巴比妥酸反应性物质来量化氧化应激水平。
治疗3个月后，哮喘患者的平均脂质过氧化物浓度显著高于健康对照者（分别为4.2±0.13微摩尔/毫升和3.6±0.07微摩尔/毫升）。
即使哮喘在治疗3个月后得到良好控制，哮喘患者的脂质过氧化物水平仍高于健康对照者。可能需要更长时间的治疗才能使脂质过氧化恢复正常。
