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结肠炎中的瞬时受体电位香草酸亚型1（TRPV1）：它是有益还是有害的受体？——一种观点

TRPV1 in colitis: is it a good or a bad receptor?--a viewpoint.

作者信息

Storr M

出版信息

Neurogastroenterol Motil. 2007 Aug;19(8):625-9. doi: 10.1111/j.1365-2982.2007.00946.x.

DOI:10.1111/j.1365-2982.2007.00946.x
PMID:17539893
Abstract

The role of the transient receptor potential vanilloid-1 (TRPV1) has been repeatedly investigated in animal models of inflammation. The present issue of Neurogastroenterology and Motility includes another report on this issue and, not unexpectedly, many questions on the precise role of TRPV1 receptors in inflammation remain unanswered. This Editorial Viewpoint discusses the present knowledge on TRPV1 receptor involvement in intestinal inflammation and discusses the question whether the TRPV1 has to be regarded as the good or the bad receptor in this context. Since TRPV1 activation turns out being a valuable approach, translation of this knowledge to human disease is highly recommended.

摘要

瞬时受体电位香草酸亚型1（TRPV1）在炎症动物模型中的作用已被反复研究。本期《神经胃肠病学与动力》杂志包含了另一篇关于此问题的报告，不出所料，关于TRPV1受体在炎症中的确切作用仍有许多问题未得到解答。本编辑观点讨论了目前关于TRPV1受体参与肠道炎症的知识，并讨论了在这种情况下TRPV1应被视为有益还是有害受体的问题。由于TRPV1激活已被证明是一种有价值的方法，强烈建议将这一知识转化应用于人类疾病。

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