Sanderson S C, Michie S
Centre for Cardiovascular Genetics, University College London, London, UK.
Clin Genet. 2007 Jun;71(6):501-10. doi: 10.1111/j.1399-0004.2007.00810.x.
As genetic tests for common gene variants and multifactorial, lifestyle-related conditions become available, it will be increasingly important to determine the psychological and behavioral impact of this emerging class of genetic tests. Our aim was to examine the potential impact of genetic testing for heart disease susceptibility on psychological predictors of smoking cessation. Two hundred and sixty-one smokers were asked to imagine that they had undergone a test for heart disease risk. They were randomly assigned to a genetic test scenario (low- or high-risk result) or an oxidative test scenario (high-risk result). Smokers in the genetic test-high risk group reported greater intention to quit smoking than smokers in the oxidative test-high risk group (p = 0.009); 30% of this was mediated by their holding stronger beliefs that quitting would reduce their heart disease risk (outcome expectations) (p = 0.011). The effect of genetic test-high risk feedback on outcome expectations was greatest amongst smokers with no heart disease family history (p = 0.038). The results suggest that genetic testing for heart disease risk may enhance interventions designed to improve health via increasing smoking cessation rates. Whether the findings hold true in studies that use real rather than hypothetical genetic tests remains to be seen.
随着针对常见基因变异以及与生活方式相关的多因素疾病的基因检测逐渐普及，确定这类新兴基因检测对心理和行为的影响变得越发重要。我们的目的是研究心脏病易感性基因检测对戒烟心理预测因素的潜在影响。261名吸烟者被要求想象自己接受了心脏病风险检测。他们被随机分配到基因检测场景组（低风险或高风险结果）或氧化检测场景组（高风险结果）。基因检测高风险组的吸烟者报告的戒烟意愿高于氧化检测高风险组的吸烟者（p = 0.009）；其中30%是由他们更坚信戒烟能降低心脏病风险（结果期望）所介导的（p = 0.011）。基因检测高风险反馈对结果期望的影响在无心脏病家族史的吸烟者中最为显著（p = 0.038）。结果表明，心脏病风险基因检测可能会通过提高戒烟率来增强旨在改善健康状况的干预措施。这些发现在使用真实而非假设性基因检测的研究中是否成立还有待观察。
