Carballido-Gamio Julio, Xu Duan, Newitt David, Han Eric T, Vigneron Daniel B, Majumdar Sharmila
Department of Radiology, University of California-San Francisco, CA 94158, USA.
Magn Reson Imaging. 2007 Jun;25(5):665-70. doi: 10.1016/j.mri.2006.10.005. Epub 2006 Nov 21.
Diffusion tensor imaging (DTI) of the lumbar spine could improve diagnostic specificity. The purpose of this work was to determine the feasibility of and to validate DTI with single-shot fast spin-echo (SSFSE) for lumbar intervertebral discs at 1.5 and 3 T. Six normal volunteers were scanned with DTI-SSFSE using an eight- and a three-b-value protocol at 1.5 and 3 T, respectively. Apparent diffusion coefficient (ADC) values were computed and validated based on those obtained at 1.5 T from corresponding diffusion tensor scans using line scan diffusion imaging (LSDI), a technique that has been previously validated for use in the spine. Pearson correlation coefficients for LSDI and DTI-SSFSE ADC values were .88 and .89 for 1.5 and 3 T, respectively, with good quantitative agreement according to the Bland-Altman method. Results indicate that DTI-SSFSE is a candidate as a clinical sequence for obtaining diffusion tensor images of the lumbar intervertebral discs with scan times shorter than 4 min.
腰椎的扩散张量成像（DTI）可提高诊断特异性。本研究的目的是确定在1.5T和3T场强下，采用单次激发快速自旋回波（SSFSE）序列进行腰椎间盘DTI检查的可行性并进行验证。分别对6名正常志愿者在1.5T和3T场强下，使用8种和3种b值方案进行DTI-SSFSE扫描。计算表观扩散系数（ADC）值，并根据之前已验证可用于脊柱的线扫描扩散成像（LSDI）技术在1.5T场强下相应扩散张量扫描获得的值进行验证。1.5T和3T场强下，LSDI与DTI-SSFSE的ADC值的Pearson相关系数分别为0.88和0.89，根据Bland-Altman方法，两者具有良好的定量一致性。结果表明，DTI-SSFSE可作为一种临床序列，用于获取腰椎间盘的扩散张量图像，扫描时间短于4分钟。
