基质金属蛋白酶-3（基质溶解素-1）在急性炎症组织损伤中的作用
Matrix metalloproteinase-3 (stromelysin-1) in acute inflammatory tissue injury.
作者信息
Nerusu Kamalakar C, Warner Roscoe L, Bhagavathula Narasimharao, McClintock Shannon D, Johnson Kent J, Varani James
机构信息
Department of Pathology, The University of Michigan Medical School, 1301 Catherine Road/Box 0602, Ann Arbor, MI 48109, USA.
出版信息
Exp Mol Pathol. 2007 Oct;83(2):169-76. doi: 10.1016/j.yexmp.2007.04.003. Epub 2007 May 4.
Mice lacking matrix metalloproteinase-3 (MMP-3; stromelysin-1) demonstrated significantly less injury than their normal counterparts following the formation of IgG-containing immune complexes in the alveolar wall or in the wall of the peritoneum. Likewise, mice lacking MMP-3 demonstrated less lung injury following intra-tracheal instillation of the chemotactic cytokine macrophage inhibitory protein-2 (MIP-2) than did mice with MMP-3. There was a relationship between tissue injury (evidenced histologically) and accumulation of anti-laminin 111 immunoreactive material in the bronchoalveolar lavage (BAL) or peritoneal lavage (PL) fluid. There was also a relationship between tissue injury and influx of neutrophils into the BAL or PL fluid. Taken together, these data demonstrate an important role for MMP-3 in acute inflammatory tissue injury.
在肺泡壁或腹膜壁形成含IgG免疫复合物后，缺乏基质金属蛋白酶-3（MMP-3；基质溶解素-1）的小鼠所受损伤明显少于正常对照小鼠。同样，与具有MMP-3的小鼠相比，缺乏MMP-3的小鼠在气管内注入趋化细胞因子巨噬细胞抑制蛋白-2（MIP-2）后肺损伤较轻。组织损伤（通过组织学证实）与支气管肺泡灌洗（BAL）液或腹腔灌洗液（PL）中抗层粘连蛋白111免疫反应性物质的积累之间存在关联。组织损伤与中性粒细胞流入BAL液或PL液之间也存在关联。综上所述，这些数据表明MMP-3在急性炎症组织损伤中起重要作用。
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