Grubb B, Folk G E
Eur J Pharmacol. 1977 Jun 1;43(3):217-23. doi: 10.1016/0014-2999(77)90020-6.
The purpose of this study was to characterize the norepinephrine (NE)-evoked calorigenic response of an isolated perfused rat muscle preparation into alpha-and/or beta-adrenergic components. Epinephrine was as effective as NE in evoking the increase in oxygen consumption. The alpha-agonist, phenylephrine, was also as effective as NE in eliciting an increase in oxygen consumption by the muscle. Isoproterenol (beta-agonist) had no effect on the VO2 of the preparation. Phentolamine, an alpha-blocker, completely blocked the NE-stimulated VO2. Propranolol (beta-antagonist) could also completely block the NE induced VO2 but this drug was found to be less potent. It was concluded that the NE-induced calorigenic response of muscle cannot be classified either strictly as an alpha-or beta-response, but unlike brown adipose tissue, the alpha-response seems to predominate in skeletal muscle. Also, it appears as though different mechanisms of action may be involved in the NE-stimulated VO2 in skeletal muscle and brown fat.
本研究的目的是将分离灌注的大鼠肌肉制剂中去甲肾上腺素（NE）诱发的产热反应区分为α-和/或β-肾上腺素能成分。肾上腺素在诱发耗氧量增加方面与NE同样有效。α-激动剂去氧肾上腺素在引发肌肉耗氧量增加方面也与NE同样有效。异丙肾上腺素（β-激动剂）对制剂的VO2没有影响。α-阻滞剂酚妥拉明完全阻断了NE刺激的VO2。普萘洛尔（β-拮抗剂）也能完全阻断NE诱导的VO2，但发现这种药物的效力较低。得出的结论是，肌肉中NE诱导的产热反应不能严格归类为α-或β-反应，但与棕色脂肪组织不同，α-反应似乎在骨骼肌中占主导地位。此外，似乎骨骼肌和棕色脂肪中NE刺激的VO2可能涉及不同的作用机制。
