Hirose Yukiko, Sasa Mitsunori, Bando Yoshimi, Hirose Toshiyuki, Morimoto Tadaoki, Kurokawa Yasushi, Nagao Taeko, Tangoku Akira
Department of Oncological and Regenerative Surgery, Institute of Health Biosciences, The University of Tokushima, 3-18-15, Kuramoto-Cho, Tokushima 770-8509, Japan.
World J Surg Oncol. 2007 Jun 2;5:60. doi: 10.1186/1477-7819-5-60.
Male breast cancer is a comparatively rare disease, and simultaneous bilateral male breast cancer is considered to be an extremely rare event. Risk factors are said to be genetic factors and hormonal abnormalities due to obesity or testicular diseases.
The patient was a 47-year-old Japanese male. His family had no history of female breast cancer. This patient also had hypospadias and hormonal examination indicated the presence of primary testicular potential hypogonadism, and these hormonal abnormalities seemed to be present since childhood or the fetal period. The bilateral breast cancer developed in this man at a comparatively young age, and histopathological studies of multiple sections showed that there was almost no normal epithelial cell in the ducts, while the ducts were almost completely filled with breast cancer cells.
It is thought that male breast cancer is caused by an imbalance between estrogen and testosterone. We cannot rule out the possibility that the breast cancer developed due to the effect of the slight elevation of estrogen over a long period of time, but the actual causative factors in this patient were unable to be definitively identified. In the future, we hope to further elucidate the causes of male breast cancer.
男性乳腺癌是一种相对罕见的疾病，而双侧同时性男性乳腺癌被认为是极其罕见的事件。据说风险因素是遗传因素以及肥胖或睾丸疾病导致的激素异常。
该患者是一名47岁的日本男性。他的家族没有女性乳腺癌病史。该患者还患有尿道下裂，激素检查显示存在原发性睾丸潜在性腺功能减退，并且这些激素异常似乎自童年期或胎儿期就已存在。这名男性双侧乳腺癌在相对年轻时发病，多切片的组织病理学研究表明，导管内几乎没有正常上皮细胞，而导管几乎完全被癌细胞填满。
认为男性乳腺癌是由雌激素和睾酮失衡引起的。我们不能排除乳腺癌是由于长期雌激素轻微升高的影响而发生的可能性，但该患者实际的致病因素无法明确确定。未来，我们希望进一步阐明男性乳腺癌的病因。
