间碘酰基苯甲酸——一种用于高效芳香族碘化反应的便捷可回收试剂。
m-Iodosylbenzoic acid - a convenient recyclable reagent for highly efficient aromatic iodinations.
作者信息
Kirschning Andreas, Yusubov Mekhman S, Yusubova Roza Y, Chi Ki-Whan, Park Joo Y
机构信息
Institut für Organische Chemie and Zentrum für Biomolekulare Wirkstoffchemie (BMWZ), Leibniz Universität Hannover, Schneiderberg 1B, D-30167 Hannover, Germany.
出版信息
Beilstein J Org Chem. 2007 Jun 4;3:19. doi: 10.1186/1860-5397-3-19.
m-Iodosylbenzoic acid performs iodinations of arenes in the presence of iodine at room temperature in acetonitrile. Separation of pure products is conveniently achieved by scavenging any aryl iodide by ion exchange with IRA-900 (hydroxide form). The reduced form of the reagent, m-iodobenzoic acid, can be easily recovered from the ion exchange resin or from the basic aqueous solution by simple acidification with HCl.
间碘酰基苯甲酸在室温下于乙腈中，在碘存在的情况下对芳烃进行碘化反应。通过用IRA - 900（氢氧化物形式）进行离子交换清除任何芳基碘化物，可方便地实现纯产物的分离。试剂的还原形式，间碘苯甲酸，可通过用盐酸简单酸化，轻松地从离子交换树脂或碱性水溶液中回收。
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