Youinou P, Jamin C, Saraux A
Laboratory of Immunology, Brest University Medical School Hospital, Brest, France.
Clin Exp Rheumatol. 2007 Mar-Apr;25(2):318-28.
The interest for B-cells in rheumatoid arthritis (RA) is currently being revived. They are involved in the development and activation of lymphoid architecture by regulating dentritic cell and T-cell function through cytokine production. Receptor editing an revising are also essential in B-cells and aid in preventing autoimmunity. Abnormalities in the subset distribution and a default in any task assigned to the B-cells may favor autoimmunity. Beneficied responses to B-cell depletion in RA by anti-CD20 monoclonal antibody rituximab illustrate the importance of B-lymphocytes in the pathogenesis of this disease. A new avenue has thus been opened, whereby B-lymphocytes return as a significant contributor to autoimmune disorders.
目前，类风湿关节炎（RA）中B细胞再次受到关注。它们通过细胞因子的产生调节树突状细胞和T细胞功能，从而参与淋巴结构的发育和激活。受体编辑和修正对B细胞也至关重要，并有助于预防自身免疫。B细胞亚群分布异常以及分配给B细胞的任何任务出现缺陷都可能有利于自身免疫。抗CD20单克隆抗体利妥昔单抗对RA中B细胞耗竭的有益反应说明了B淋巴细胞在该疾病发病机制中的重要性。因此，一条新途径已经开启，即B淋巴细胞再次成为自身免疫性疾病的重要促成因素。
