Habukawa Mitsunari, Uchimura Naohisa, Maeda Masaharu, Kotorii Nozomu, Maeda Hisao
Department of Neuropsychiatry, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Biol Psychiatry. 2007 Nov 15;62(10):1179-82. doi: 10.1016/j.biopsych.2007.01.007. Epub 2007 Jun 1.
Laboratory sleep studies in posttraumatic stress disorder (PTSD) have not provided consistent evidence of sleep disturbance, despite apparent sleep complaints. Most of these studies have investigated middle-aged chronic PTSD subjects with a high prevalence of comorbidities such as substance dependence and/or personality disorder.
Ten young adult PTSD patients (aged 23.4 +/- 6.1 years) without comorbidities of substance dependence and/or personality disorder underwent 2-night polysomnographic recordings. These sleep measures were compared with those of normal control subjects and were correlated with PTSD symptoms.
Posttraumatic stress disorder patients demonstrated significantly poorer sleep, reduced sleep efficiency caused by increased wake time after sleep onset, and increased awakening from rapid eye movement (REM) sleep (REM interruption). We found significant positive correlations between the severity of trauma-related nightmare complaints and the percentage of REM interruption, as well as wake time after sleep onset.
The results indicate that trauma-related nightmares are an important factor resulting in increased REM interruptions and wake time after sleep onset in PTSD.
尽管创伤后应激障碍（PTSD）患者明显存在睡眠问题，但实验室睡眠研究并未提供一致的睡眠障碍证据。这些研究大多调查的是中年慢性PTSD患者，他们存在物质依赖和/或人格障碍等共病的患病率较高。
10名无物质依赖和/或人格障碍共病的年轻成年PTSD患者（年龄23.4±6.1岁）接受了为期两晚的多导睡眠图记录。将这些睡眠指标与正常对照受试者的指标进行比较，并与PTSD症状相关联。
创伤后应激障碍患者表现出明显较差的睡眠，睡眠起始后觉醒时间增加导致睡眠效率降低，以及快速眼动（REM）睡眠觉醒增加（REM中断）。我们发现，与创伤相关的噩梦主诉严重程度与REM中断百分比以及睡眠起始后的觉醒时间之间存在显著正相关。
结果表明，与创伤相关的噩梦是导致PTSD患者REM中断增加和睡眠起始后觉醒时间增加的重要因素。
