Kartasheva V I, Donov G I, Fomenko T M, Klimov Iu V, Osminina M K
Pediatriia. 1991(7):69-74.
To suppress the activity of glomerulonephritis, lupus and primary chronic mixed one, 13 children received plasmapheresis synchronously with pulse therapy with cyclophosphamide or prednisolone. Plasmapheresis was carried out daily for 3 days. Six hours after the last session and on days 4 and 5 of the treatment pulse therapy was provided, followed by conventional intake of prednisolone per os in combination with azathioprine or cyclophosphamide. Beneficial therapeutic results were obtained in 10 patients within 3 to 6 weeks. The effect turned out insufficient in a patient with associated systemic lupus erythematosus, and rapid-progressing nephritis and in a child with primary chronic glomerulonephritis of the mesangiocapillary type with fibroplastic transformation and persistent nephrotic syndrome. No therapeutic effect was attained in a patient with focal segmental glomerulosclerosis running its course with long persistent nephrotic syndrome.
为抑制肾小球肾炎、狼疮及原发性慢性混合型疾病的活动，13名儿童在接受环磷酰胺或泼尼松龙脉冲治疗的同时同步进行了血浆置换。血浆置换每天进行1次，共3天。在最后一次治疗后的6小时以及治疗的第4天和第5天进行脉冲治疗，随后口服常规剂量的泼尼松龙并联合硫唑嘌呤或环磷酰胺。10例患者在3至6周内获得了有益的治疗效果。对于一名伴有系统性红斑狼疮、快速进展性肾炎的患者以及一名患有伴有纤维增生性转化和持续性肾病综合征的系膜毛细血管型原发性慢性肾小球肾炎的儿童，治疗效果欠佳。对于一名患有局灶节段性肾小球硬化且病程伴有长期持续性肾病综合征的患者，未获得治疗效果。
