Korovina N A, Levitskaia S V, Reshetniak G P, Iur'eva E A, Pykov M I
Pediatriia. 1991(9):41-5.
To estimate the information content of different methods of diagnosing biliary diseases, 103 children aged 5 to 15 years, including 25 practically healthy children as control, were examined. Abdominal organs, particularly the liver and gallbladder were examined by echography. The duodenal contents was explored by microscopy of the sediment and biochemistry which included analysis in the vesicular and liver portions of the concentrations of phospholipids, activity of phospholipases A and C as well as measurements of creatine kinase, lactate dehydrogenase, alkaline phosphatase, C-reactive protein and of the diphenylamine index. Ultrasonography was found to be highly informative. The characteristic echographic alterations seen in dyskinesia of the biliary tract, dyscholias and chronic cholecystitis were defined. For differential diagnosis of dyscholia and chronic cholecystitis it is necessary to carry out biochemistry of the duodenal contents including measurements of phospholipids, activity of phospholipases A and C, alkaline phosphatase, creatine kinase, lactate dehydrogenase, C-reactive protein and the diphenylamine index. Based on the similarity of the alterations seen in children with different cholepathies, a concept is advanced of the mechanisms by which functional and organic diseases of the gallbladder are formed.
为评估不同胆道疾病诊断方法的信息量，对103名5至15岁儿童进行了检查，其中包括25名实际健康儿童作为对照。通过超声检查腹部器官，特别是肝脏和胆囊。通过沉淀物显微镜检查和生物化学方法检测十二指肠内容物，包括分析磷脂在囊泡和肝脏部分的浓度、磷脂酶A和C的活性，以及测量肌酸激酶、乳酸脱氢酶、碱性磷酸酶、C反应蛋白和二苯胺指数。发现超声检查具有很高的信息量。确定了在胆道运动障碍、胆汁淤积和慢性胆囊炎中可见的特征性超声改变。为鉴别胆汁淤积和慢性胆囊炎，有必要对十二指肠内容物进行生物化学检测，包括测量磷脂、磷脂酶A和C的活性、碱性磷酸酶、肌酸激酶、乳酸脱氢酶、C反应蛋白和二苯胺指数。基于不同胆病患儿所见改变的相似性，提出了胆囊功能性和器质性疾病形成机制的概念。
