Choi Brian G, McLaughlin Mary Ann
The Zena and Michael A. Wiener Cardiovascular Institute, The Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA.
Endocrinol Metab Clin North Am. 2007 Jun;36(2):365-77. doi: 10.1016/j.ecl.2007.03.011.
Coronary artery disease (CAD) mortality differs in men and women, leading to the speculation that differences in sex steroids contribute to risk. Controlled clinical trials have shown that estrogen replacement is not cardioprotective in certain women, and recent cross-sectional studies associate low testosterone with a greater incidence of CAD in men. Testosterone has demonstrated effects on insulin resistance, obesity, myocardium, coagulation, inflammation, vasodilation, and endothelial function. Imbalance of sex steroids contributes to adverse cardiac effects in men.
冠状动脉疾病（CAD）的死亡率在男性和女性中存在差异，这引发了关于性类固醇差异导致风险的猜测。对照临床试验表明，雌激素替代疗法对某些女性并无心脏保护作用，并且最近的横断面研究表明，低睾酮水平与男性CAD发病率较高相关。睾酮已被证明对胰岛素抵抗、肥胖、心肌、凝血、炎症、血管舒张和内皮功能有影响。性类固醇失衡会对男性心脏产生不良影响。
