Paquet Claire, Boissonnot Michèle, Roger Florent, Dighiero Paul, Gil Roger, Hugon Jacques
Department of Neurology, Poitiers University Hospital, 86021 Poitiers, France.
Neurosci Lett. 2007 Jun 13;420(2):97-9. doi: 10.1016/j.neulet.2007.02.090. Epub 2007 Mar 19.
In Alzheimer's disease (AD), brain lesions are marked by severe neuronal loss and retinal degeneration was previously mentioned in affected patients. Mild cognitive impairment (MCI) is a clinical syndrome that could be an early phase of AD. In this study, using optical coherence tomography (OCT), the retinal nerve fiber layer (RNFL) thickness was assessed in patients with mild AD, moderate to severe AD, amnestic MCI and control subjects. The results show that RNFL thickness is statistically reduced in patients with MCI, mild AD or moderate to severe AD compared to controls. In addition, no statistical difference was found between the results in MCI patients and mild AD patients. The RNFL seems to be involved early during the course of amnestic MCI and OCT tests could be carried out in patients with cognitive troubles.
在阿尔茨海默病（AD）中，脑损伤以严重的神经元丧失为特征，且先前已提及患病患者存在视网膜变性。轻度认知障碍（MCI）是一种临床综合征，可能是AD的早期阶段。在本研究中，使用光学相干断层扫描（OCT）对轻度AD患者、中度至重度AD患者、遗忘型MCI患者及对照受试者的视网膜神经纤维层（RNFL）厚度进行了评估。结果显示，与对照组相比，MCI患者、轻度AD患者或中度至重度AD患者的RNFL厚度在统计学上有所降低。此外，MCI患者和轻度AD患者的结果之间未发现统计学差异。RNFL似乎在遗忘型MCI病程早期就受到影响，对于有认知问题的患者可以进行OCT检测。
