Charbonnel B
Sem Hop. 1975 Nov 23;-51(46):2793-2804.
The prostaglandins probably play an important role in the physiology of reproduction. In women as in men, they intervene at several levels. At the level of the ovary, the prostaglandins E may be modulators of the action of gonadostimulin on ovarian hormonogenesis, in close relationship with cyclic AMP and, furthermore, represent an important biochemical intermediate stage in the mechanism of ovulation. F2 prostaglandin, F2 alpha, on the other hand, represents in numerous animals, but not in women, a luteolytic factor of uterine origin. At the level of the hypothalamopituitary axis, E prostaglandins may modulate hypothalamic neuro-secretion and to a lesser degree, the liberation of pituitary stimulins, and thus intervene in gonadotropic function. At the level of the female genital tract, prostaglandins may influence uterine and tubal motility. It is perhaps by this latter effect that the very large quantities of seminal prostaglandin influence the process of fertilisation.
前列腺素可能在生殖生理过程中发挥重要作用。在女性和男性中，它们在多个层面发挥作用。在卵巢层面，前列腺素E可能是促性腺激素对卵巢激素生成作用的调节剂，与环磷酸腺苷密切相关，此外，它还是排卵机制中的一个重要生化中间阶段。另一方面，前列腺素F2，即F2α，在许多动物中是子宫来源的黄体溶解因子，但在女性中并非如此。在下丘脑-垂体轴层面，前列腺素E可能调节下丘脑神经分泌，并在较小程度上调节垂体刺激素的释放，从而干预促性腺功能。在女性生殖道层面，前列腺素可能影响子宫和输卵管的蠕动。也许正是通过后一种作用，大量的精液前列腺素才会影响受精过程。
