Flierman Roelof, Daha Mohamed R
Leiden University Medical Center, Department of Nephrology, Leiden, The Netherlands.
Immunobiology. 2007;212(4-5):363-70. doi: 10.1016/j.imbio.2006.11.005. Epub 2006 Dec 21.
The complement system is implicated among others in the clearance of apoptotic cells, and deficiency for different components of the complement system is associated with aberrant handling of apoptotic material. As a result of this, it is thought that the complement system is involved in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE) which affects multiple organs. In this review, the authors highlight the available data on complement and apoptosis, as well as the role of complement in severe autoimmune diseases like SLE.
补体系统尤其在凋亡细胞的清除过程中发挥作用，补体系统不同成分的缺陷与凋亡物质的异常处理有关。由此，人们认为补体系统参与了自身免疫性疾病如系统性红斑狼疮（SLE）的发病机制，系统性红斑狼疮会影响多个器官。在这篇综述中，作者强调了关于补体与凋亡的现有数据，以及补体在系统性红斑狼疮等严重自身免疫性疾病中的作用。
