Aly N M, Playfer J R, Smith S L, Halliday D M
University Hospital Aintree, Liverpool, UK.
Age Ageing. 2007 Jul;36(4):395-9. doi: 10.1093/ageing/afm061. Epub 2007 Jun 1.
Parkinson's disease (PD) is a common neurodegenerative disease and the diagnosis of its idiopathic form remains challenging. The diagnosis of idiopathic form is based on clinical features which can have poor sensitivity with about 25% of patients diagnosed as having the disease actually having other conditions. In this study we assess the suitability and clinical value of a low cost computer-based system as an aid to diagnosis of PD, in particular the presence of tremor. All participants (12 patients and 10 controls) performed a shape-tracing task using a graphic tablet attached to a laptop. To assess the presence of tremors in the collected data, a statistical spectral analysis of the moment-to-moment fluctuations in the position signal of the output from the digitising tablet was performed. This allowed the comparison of power spectrums obtained from the control and patient responses respectively. A peak in log power between the 5 Hz & 6 Hz can clearly be identified in the patient's spectrum and is indicative of Parkinson's related tremor and no similar peak could be seen in the control's spectrum, suggesting this type of sequential task and automated data analysis may be useful in the diagnosis of tremor.
帕金森病（PD）是一种常见的神经退行性疾病，其特发性形式的诊断仍然具有挑战性。特发性形式的诊断基于临床特征，而这些特征的敏感性可能较差，约25%被诊断患有该疾病的患者实际上患有其他病症。在本研究中，我们评估了一种低成本的基于计算机的系统作为辅助PD诊断，特别是震颤检测的适用性和临床价值。所有参与者（12名患者和10名对照）使用连接到笔记本电脑的图形输入板执行了形状追踪任务。为了评估收集数据中震颤的存在，对数字化输入板输出的位置信号的瞬间波动进行了统计频谱分析。这使得能够分别比较从对照和患者反应中获得的功率谱。在患者的频谱中可以清楚地识别出5Hz至6Hz之间的对数功率峰值，这表明与帕金森病相关的震颤，而在对照的频谱中未观察到类似的峰值，这表明这种类型的序列任务和自动化数据分析可能有助于震颤的诊断。
