Abraham Robert T, Gibbons James J
Department of Oncology Discovery, Wyeth, Pearl River, New York 10960, USA.
Clin Cancer Res. 2007 Jun 1;13(11):3109-14. doi: 10.1158/1078-0432.CCR-06-2798.
The immunosuppressive drug rapamycin played a key role in the functional characterization of mammalian target of rapamycin (mTOR), an unusual protein kinase that coordinates growth factor and nutrient availability with cell growth and proliferation. Several rapamycin-related compounds are now in various stages of clinical development as anticancer agents. This article highlights recent advances in our understanding of the mTOR signaling pathway and the implications of these findings for the clinical application of mTOR inhibitors in cancer patients.
免疫抑制药物雷帕霉素在雷帕霉素哺乳动物靶点（mTOR）的功能特性研究中发挥了关键作用，mTOR是一种独特的蛋白激酶，它将生长因子和营养物质的可利用性与细胞生长及增殖协调起来。目前，几种与雷帕霉素相关的化合物正处于作为抗癌药物的不同临床开发阶段。本文重点介绍了我们对mTOR信号通路理解的最新进展，以及这些发现对mTOR抑制剂在癌症患者临床应用中的意义。
