Beaumont Hanneke, Boeckxstaens Guy
Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, the Netherlands.
Curr Opin Gastroenterol. 2007 Jul;23(4):416-21. doi: 10.1097/MOG.0b013e3281299000.
Every year more insight into the pathogenesis and treatment of esophageal motor disorders is obtained. This review highlights some interesting literature published in this area during the last year.
Longitudinal and circular muscle contractions act in a well coordinated fashion to allow normal peristalsis. Techniques such as intraluminal impedance, high-resolution manometry and intraluminal ultrasound provide useful additional information on esophageal function both in the normal and abnormal situation. The dynamics of the gastroesophageal junction can be studied with a newly developed probe, and the mechanism behind transient lower esophageal sphincter relaxations is still being unravelled. New manometric criteria for nutcracker esophagus have been proposed, whereas further evidence is reported supporting an association between diabetes mellitus and cardiovascular disease and esophageal dysmotility and spasm, respectively. Finally, several long-term follow-up results of surgical myotomy and pneumodilatation have been reported.
Due to the perfection of esophageal measuring techniques, our knowledge of esophageal function continues to increase. The studies reviewed here provide interesting information on the pathogenesis and treatment of several esophageal motor disorders.
每年人们对食管运动障碍的发病机制和治疗都有了更多的认识。本综述重点介绍了去年该领域发表的一些有趣文献。
纵行肌和环行肌以协调良好的方式收缩，以实现正常蠕动。腔内阻抗、高分辨率测压和腔内超声等技术为正常和异常情况下的食管功能提供了有用的额外信息。可以使用新开发的探头研究胃食管交界处的动力学，而一过性下食管括约肌松弛背后的机制仍在研究中。已经提出了胡桃夹食管的新测压标准，同时有进一步证据表明糖尿病与心血管疾病、食管动力障碍和痉挛之间分别存在关联。最后，报告了手术肌切开术和气囊扩张术的一些长期随访结果。
由于食管测量技术的完善，我们对食管功能的认识不断增加。这里综述的研究提供了关于几种食管运动障碍的发病机制和治疗的有趣信息。
