Laverdant C, Cristau P, Essioux H, Molinie C, Gendron Y, Bernard J, Kassem A
Sem Hop. 1975 Mar 26;51(15):1001-7.
Discussions having lately raised the importance of rest in the treatment of viral hepatitis the authors report some studies made on the subject. They take into account 3 personal unpublished statistics analyzing the role of effort at 3 different stages -- in the acute phase, during convalescence and as an eventual factor producing aggravation. Although their results appear to be in contradiction with those found in American studies the authors show that the importance of rest in the initial phase is unanimously recognized and that there is no statistical evidence that such a prescription should be given up before the normalization of the main biological parameters. Furthermore though it is statistically proved that a certain activity between the 30th and 60th day does not affect the later course of the disease yet there is no element which allows to authorize the patient to resume his normal professionnal activity before the 60th day. Finally the lack of controlled studies does not allow any precise determination of the impact of effort in the determinism of an eventual aggravation. However according to the authors' experience physical tiredness can legitimately be suspected to have produced this aggravation in 47.06 % of cases of a secondarily aggravated hepatitis.
鉴于最近关于休息在病毒性肝炎治疗中的重要性的讨论,作者报告了一些关于该主题的研究。他们考虑了3项个人未发表的统计数据,分析了在3个不同阶段——急性期、恢复期以及作为最终导致病情加重的因素——努力所起的作用。尽管他们的结果似乎与美国研究的结果相矛盾,但作者表明,休息在初始阶段的重要性得到了一致认可,而且没有统计证据表明在主要生物学参数恢复正常之前就应该放弃这样的医嘱。此外,虽然从统计学上证明在第30天至60天之间进行一定活动不会影响疾病的后期进程,但没有任何因素允许患者在第60天之前恢复其正常职业活动。最后,缺乏对照研究使得无法精确确定努力在最终病情加重的决定因素中所起的作用。然而,根据作者的经验,在继发性加重型肝炎的47.06%的病例中,可以合理怀疑身体疲劳导致了这种病情加重。