Santovito A, Selvaggi A, Cervella P, Castellano S, Bigatti M P, Sella G, Delpero M
Dipartimento di Biologia Animale e dell'Uomo, Università di Torino, Torino, Italy.
Am J Hum Biol. 2007 Jul-Aug;19(4):589-92. doi: 10.1002/ajhb.20605.
We analyzed the frequencies of eight human polymorphic Alu insertion loci in population samples from five towns in North-West Italy: Postua, Cavaglià, Biella, Torino, and Genova. All loci under scrutiny were found to be polymorphic in all samples, with the two exceptions of locus A25 in Postua, which was fixed for the absence of the Alu element, and APO in Genova, where the Alu insertion was fixed. Heterozigosity values were highly variable in all loci. F(ST) values for all loci indicate that most of the variability is found within populations, while between population variability is lower. In the multidimensional scaling (MDS) analysis plot, the studied populations are separated from the main group represented by European populations. The Postua sample is set apart also from neighboring towns as Cavaglià and Biella, confirming previous observations of the demographic isolation of this population.
我们分析了意大利西北部五个城镇（波斯图阿、卡瓦利亚、比耶拉、都灵和热那亚）人群样本中八个人类多态性Alu插入位点的频率。所有受检测的位点在所有样本中均为多态性，但有两个例外，即波斯图阿的A25位点固定为不存在Alu元件，热那亚的APO位点Alu插入是固定的。所有位点的杂合度值变化很大。所有位点的F(ST)值表明，大部分变异存在于群体内部，而群体间的变异较低。在多维尺度分析（MDS）图中，所研究的群体与以欧洲群体为代表的主要群体分开。波斯图阿样本也与卡瓦利亚和比耶拉等邻近城镇不同，证实了此前关于该群体人口隔离的观察结果。
