Klotz H P, Delorme M L, Ochoa F, Aussenard C
Sem Hop. 1975 Apr 26;51(20):1333-6.
The increase in serum calcitonin during pregnoncy raises the problem of the role of oestrogens in the secretion of calcitonin. The authors show that oestrogen causes, in castrated rats, an increase in calcitonin activity as measured in the plasma by a biological method. This effect of injected oestrogen does not occur if the castrated animal is also submitted to thyroidectomy. The effects of progesterone studied on a small number of cases, seem to be less marked. This report shows that oestrogens have a synergistic effect with calcitonin in the maintenance of calcium within the bone. This is of importance during pregnancy and after the menopause.
孕期血清降钙素水平升高引发了雌激素在降钙素分泌中作用的问题。作者表明，在去势大鼠中，雌激素会使通过生物学方法测定的血浆降钙素活性增加。如果对去势动物同时进行甲状腺切除术，注射雌激素的这种作用就不会出现。对少数病例研究的孕酮作用似乎不太明显。本报告表明，雌激素在维持骨内钙含量方面与降钙素具有协同作用。这在孕期和绝经后具有重要意义。
