Koo Winston W K, Hammami Mouhanad, Hockman Elaine M
The Carman and Ann Adams Department of Pediatrics, Wayne State University and Hutzel Hospital, Wayne State University, Detroit, Michigan, USA.
Nutr J. 2007 Jun 4;6:11. doi: 10.1186/1475-2891-6-11.
Leptin and its soluble receptor (sOB-R) are important to regulation of body composition but there are no data on the developmental variations in these plasma variables and their relationship with body composition measurements,
Weight, length, and body composition (bone, fat and lean mass) by dual energy absorptiometry, and plasma variables were measured in healthy infants at 2, 4, 8 and 12 months.
15 whites and 29 African Americans (21 males and 23 females) with mean birth weight 3357 +/- 45 (SEM) g and gestation of 39.3 +/- 0.17 weeks were studied. The overall Z score for weight, length and weight for length during the study were 0.00 +/- 0.15, -0.08 +/- 0.11 and 0.12 +/- 0.14 respectively. With increasing age, plasma leptin (1.0 to 18.2, median 5.5 ng/mL) and sOB-R:leptin molar ratio (10.1 to 247.4, median 59.9) were lowered (r = -0.47, p < 0.01; and r = -0.37, p < 0.05 respectively), best predicted by weight Z score and percentage of fat mass, and higher in African American and female. Presence of body composition measurements eliminated the race and gender effect on the plasma variables. Plasma sOB-R (49.5 to 173.9, median 81.3 ng/mL) did not change significantly with age and was correlated and predicted only by body composition measurements.
In healthy growing infants, plasma leptin but not sOB-R decreases with age. Gender, race and anthropometric measurements are additional physiological determinants predictive of plasma leptin and the receptor:ligand ratio. However, body composition is the only variable that can predict plasma leptin and its soluble receptor and the receptor: ligand ratio; and body composition measurements eliminated the race and gender effect on these plasma variables.
瘦素及其可溶性受体（sOB-R）对身体成分的调节很重要，但关于这些血浆变量的发育变化及其与身体成分测量值之间的关系尚无数据。
对健康婴儿在2、4、8和12个月时测量体重、身长、通过双能吸收法测量身体成分（骨骼、脂肪和瘦体重）以及血浆变量。
研究了15名白人婴儿和29名非裔美国婴儿（21名男性和23名女性），平均出生体重3357±45（SEM）克，妊娠39.3±0.17周。研究期间体重、身长和身长别体重的总体Z评分分别为0.00±0.15、-0.08±0.11和0.12±0.14。随着年龄增长，血浆瘦素（1.0至18.2，中位数5.5 ng/mL）和sOB-R:瘦素摩尔比（10.1至247.4，中位数59.9）降低（r分别为-0.47，p<0.01；r为-0.37，p<0.05），最佳预测指标是体重Z评分和脂肪量百分比，且在非裔美国人和女性中更高。身体成分测量值的存在消除了种族和性别对血浆变量的影响。血浆sOB-R（49.5至173.9，中位数81.3 ng/mL）随年龄无显著变化，仅与身体成分测量值相关且可由其预测。
在健康成长的婴儿中，血浆瘦素随年龄降低，而sOB-R则不然。性别、种族和人体测量指标是预测血浆瘦素及其受体:配体比值的额外生理决定因素。然而，身体成分是唯一能够预测血浆瘦素及其可溶性受体以及受体:配体比值的变量；并且身体成分测量值消除了种族和性别对这些血浆变量的影响。
