Cooper William O, Willy Mary E, Pont Stephen J, Ray Wayne A
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232-2504, USA.
Am J Obstet Gynecol. 2007 Jun;196(6):544.e1-5. doi: 10.1016/j.ajog.2007.01.033.
The purpose of this study was to quantify the rate of exposures to antidepressants during pregnancy in a large cohort of women.
This was a retrospective cohort study of 105,335 pregnancies among women enrolled in Tennessee Medicaid from 1999-2003. Pregnancies were classified according to antidepressant exposures during pregnancy using previously validated computerized pharmacy records linked with birth certificates.
During the study period, 8.7% of women giving birth had exposure to any antidepressant; 6.2% had exposure to a selective serotonin reuptake inhibitor. Maternal age > 25 years (P < .0001), white race (P < .0001), and education > 12 years (P = .008) were significant predictors of antidepressant exposure. The proportion of pregnancies with antidepressant use increased from 5.7% of pregnancies in 1999 to 13.4% of pregnancies in 2003 (p < .0001). The increase was mostly accounted for by increases in selective serotonin reuptake inhibitor exposures.
There is an urgent need for further studies that better quantify the fetal consequences of exposure to antidepressants.
本研究的目的是对一大群孕妇在孕期使用抗抑郁药的比例进行量化。
这是一项对1999年至2003年参加田纳西州医疗补助计划的105335名孕妇进行的回顾性队列研究。根据与出生证明相关的先前经验证的计算机化药房记录，将妊娠按照孕期抗抑郁药使用情况进行分类。
在研究期间，8.7%的分娩女性使用过任何抗抑郁药；6.2%使用过选择性5-羟色胺再摄取抑制剂。母亲年龄>25岁（P<.0001）、白人种族（P<.0001）以及受教育程度>12年（P=.008）是抗抑郁药使用的显著预测因素。孕期使用抗抑郁药的妊娠比例从1999年的5.7%增至2003年的13.4%（P<.0001）。这种增加主要是由于选择性5-羟色胺再摄取抑制剂使用的增加。
迫切需要开展进一步研究，以更好地量化接触抗抑郁药对胎儿的影响。
