Cheng Yvonne W, Hopkins Linda M, Laros Russell K, Caughey Aaron B
Division of Perinatal Medicine and Genetics, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, School of Medicine, San Francisco, CA, USA.
Am J Obstet Gynecol. 2007 Jun;196(6):585.e1-6. doi: 10.1016/j.ajog.2007.03.021.
This study was undertaken to examine perinatal outcomes associated with the second stage of labor in multiparous women.
This is a retrospective cohort study of all term, cephalic, singleton births delivered by multiparous women between 1991 and 2001. Duration of the second stage of labor was stratified into hourly intervals: 0-1 hour, 1-2 hours, 2-3 hours, and 3 hours or longer. Perinatal outcomes were analyzed by using chi2 test and multivariable logistic regression models, by using P<.05 and 95% CI to indicate statistical significance.
Compared with women who delivered between the 0- and 2-hour interval, women with a second stage more than 3 hours had higher risks of operative vaginal deliveries (odds ratio = 13.27; 95% CI [9.38-18.8]), cesarean deliveries (odds ratio = 6.00; [4.06-8.86]), and maternal morbidity including third- or fourth-degree perineal lacerations, postpartum hemorrhage, and chorioamnionitis. Their neonates had higher risks of 5-minute Apgar score less than 7 (odds ratio = 3.63; 95% CI [1.77-7.43]), meconium stained amniotic fluid (odds ratio = 1.44; 95% CI [1.07-1.94]), admission to intensive care nursery (odds ratio = 2.08; 95% CI [1.15-3.77]), composite neonatal morbidity (odds ratio = 1.85; 95% CI [1.23-2.77]), and longer neonatal stay in the hospital (odds ratio = 1.67; 95% CI [1.11-2.51]).
Multiparous women with a second stage of 3 hours or greater are at increased risks for operative deliveries, peripartum morbidity, and undesirable neonatal outcomes. These outcomes should be considered in the management of multiparous women with a second stage of labor beyond 3 hours.
本研究旨在探讨经产妇第二产程相关的围产期结局。
这是一项对1991年至2001年间经产妇足月、头位、单胎分娩的回顾性队列研究。第二产程持续时间按每小时区间分层:0 - 1小时、1 - 2小时、2 - 3小时和3小时及更长时间。采用卡方检验和多变量逻辑回归模型分析围产期结局,以P<0.05和95%置信区间表示统计学意义。
与在0至2小时区间分娩的女性相比,第二产程超过3小时的女性进行阴道助产分娩的风险更高(比值比 = 13.27;95%置信区间[9.38 - 18.8])、剖宫产分娩的风险更高(比值比 = 6.00;[4.06 - 8.86]),且产妇发病率更高,包括会阴三度或四度裂伤、产后出血和绒毛膜羊膜炎。她们的新生儿5分钟阿氏评分低于7分的风险更高(比值比 = 3.63;95%置信区间[1.77 - 7.43])、羊水粪染的风险更高(比值比 = 1.44;95%置信区间[1.07 - 1.94])、入住重症监护病房的风险更高(比值比 = 2.08;95%置信区间[1.15 - 3.77])、综合新生儿发病率更高(比值比 = 1.85;95%置信区间[1.23 - 2.77]),以及新生儿住院时间更长(比值比 = 1.67;95%置信区间[1.11 - 2.51])。
第二产程达3小时或更长时间的经产妇进行手术分娩、围产期发病及不良新生儿结局的风险增加。在管理第二产程超过3小时的经产妇时应考虑这些结局。