Menshanov Petr N, Dygalo Nikolay N
Functional Neurogenomics Laboratory, Institute of Cytology and Genetics, Russian Academy of Science, Lavrentjev av. 10, 630090 Novosibirsk, Russian Federation.
J Neurosci Methods. 2007 Aug 30;164(2):299-303. doi: 10.1016/j.jneumeth.2007.04.014. Epub 2007 May 4.
Automated registration of neonatal rat entries in the squares of a testing chamber is suggested for the animal locomotion assessment. This method allows detection of paddling and pivoting activities that are not accompanied by forward movement of the animal. The proposed technique is also relatively insensitive to nonlocomotor changes in a pup's body position, such as breathing and shaking, and thus offers a selective detection of locomotor-related activity. The application of the method permits the evaluation of spontaneous and stimulated motor activity of neonatal rats using relatively short test duration and a minimal number of animals.
建议采用自动记录新生大鼠在测试箱方格中的活动情况来评估动物的运动能力。这种方法能够检测到动物不伴有向前移动的划水和旋转活动。所提出的技术对幼崽身体位置的非运动性变化（如呼吸和颤抖）也相对不敏感，因此能够选择性地检测与运动相关的活动。该方法的应用允许使用相对较短的测试时间和最少数量的动物来评估新生大鼠的自发和刺激运动活动。
