脂质II的腺苷膦酸酯抑制剂：来自肺炎链球菌的丙氨酰tRNA连接酶MurM
Adenosine phosphonate inhibitors of lipid II: alanyl tRNA ligase MurM from Streptococcus pneumoniae.
作者信息
Cressina Elena, Lloyd Adrian J, De Pascale Gianfranco, Roper David I, Dowson Christopher G, Bugg Timothy D H
机构信息
Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
出版信息
Bioorg Med Chem Lett. 2007 Aug 15;17(16):4654-6. doi: 10.1016/j.bmcl.2007.05.071. Epub 2007 May 25.
PMID:17548193
Abstract
Adenosine and 2'-deoxyadenosine phosphonate transition state analogues act as the first inhibitors for the MurMN/FemABX family of tRNA-dependent ligases implicated in high-level penicillin resistance in gram-positive bacteria.
摘要
腺苷和2'-脱氧腺苷膦酸过渡态类似物作为MurMN/FemABX家族tRNA依赖性连接酶的首批抑制剂，该家族与革兰氏阳性菌的高水平青霉素抗性有关。
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