Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres.

作者信息

Liger François, Popowycz Florence, Besson Thierry, Picot Laurent, Galmarini Carlos M, Joseph Benoît

机构信息

Laboratoire de Chimie Organique 1, UMR - CNRS 5181, Université Claude Bernard - Lyon 1, Bâtiment 308 - CPE, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex, France.

出版信息

Bioorg Med Chem. 2007 Aug 15;15(16):5615-9. doi: 10.1016/j.bmc.2007.05.033. Epub 2007 May 18.

DOI:10.1016/j.bmc.2007.05.033

PMID:17548198

Abstract

Aza-analogues of clausine E, mukonine and koenoline were prepared from 1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde and their antiproliferative activity was evaluated against miscellaneous cancer cell lines and compared to those obtained with clausine E and mukonine.

摘要

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