原发性进展型多发性硬化症：诊断标准的比较研究
Primary progressive multiple sclerosis: a comparative study of the diagnostic criteria.
作者信息
de Seze J, Debouverie M, Waucquier N, Steinmetz G, Pittion S, Zephir H, Fleury M, Blanc F, Vermersch P
机构信息
Department of Neurology, Hôpital Civil, Strasbourg, France.
出版信息
Mult Scler. 2007 Jun;13(5):622-5. doi: 10.1177/1352458506071767. Epub 2007 Feb 16.
We assessed the different sets of diagnostic criteria for primary progressive multiple sclerosis (PPMS), in order to determine their sensitivity when applied to a cohort of 261 PPMS patients. According to the Thompson criteria, 168 patients (64.4%) had definite PPMS, 84 patients (32.2%) had probable PPMS, and nine patients (3.4%) had possible PPMS; according to the McDonald criteria, 180 patients (69%) had PPMS; according to the revised McDonald criteria, 194 patients (74.3%) had PPMS. Our findings indicate that the revised McDonald criteria are more sensitive than the original McDonald criteria, but less sensitive than the Thompson criteria.
我们评估了原发性进行性多发性硬化症（PPMS）的不同诊断标准集，以确定其应用于261例PPMS患者队列时的敏感性。根据汤普森标准，168例患者（64.4%）患有确诊的PPMS，84例患者（32.2%）患有可能的PPMS，9例患者（3.4%）患有疑似PPMS；根据麦克唐纳标准，180例患者（69%）患有PPMS；根据修订后的麦克唐纳标准，194例患者（74.3%）患有PPMS。我们的研究结果表明，修订后的麦克唐纳标准比原始麦克唐纳标准更敏感，但比汤普森标准敏感性低。
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