Dowidar N, Moesgaard F, Matzen P
Dept. of Medical and Surgical Gastroenterology, Hvidovre Hospital, University of Copenhagen, Denmark.
Scand J Gastroenterol. 1991 Nov;26(11):1132-6. doi: 10.3109/00365529108998604.
This study included 236 patients treated with endoscopic biliary endoprostheses. Malignant strictures were responsible for the obstruction in 87% of the patients. The 1-week and 1-month mortality for patients with malignant strictures was 10% and 22%, respectively, whereas that of patients with benign conditions was 3% and 10%, respectively. The major complication encountered was the frequent hospital readmissions of patients owing to clogging of their endoprostheses. Late clogging had an overall occurrence of 33% and presented with recurrence of jaundice with or without fever or pain. Late signs of cholangitis occurred in 15% of the patients, whereas other late complications were rather infrequent. Although 10-french endoprostheses had a significantly longer patency period than 7-french--that is, 6 months versus 2 months (p = 0.01)--the proportion of patients in whom clogging occurred was nearly the same, 30% for 10-french and 32% for 7-french endoprostheses.
本研究纳入了236例接受内镜胆管内支架置入术治疗的患者。87%的患者梗阻由恶性狭窄所致。恶性狭窄患者的1周和1个月死亡率分别为10%和22%，而良性病变患者的1周和1个月死亡率分别为3%和10%。主要并发症是患者因内支架堵塞频繁再次入院。晚期堵塞的总体发生率为33%，表现为黄疸复发，伴有或不伴有发热或疼痛。15%的患者出现胆管炎晚期征象，而其他晚期并发症较少见。尽管10F的内支架通畅期明显长于7F的内支架，即6个月对2个月（p = 0.01），但发生堵塞的患者比例几乎相同，10F内支架为30%，7F内支架为32%。
