Das S K, Bose P, Biswas A, Dutt A, Banerjee T K, Hazra A M, Raut D K, Chaudhuri A, Roy T
Department of Neurology, Bangur Institute of Neurology, Kolkata, India.
Neurology. 2007 Jun 5;68(23):2019-26. doi: 10.1212/01.wnl.0000264424.76759.e6.
To estimate the prevalence of two types of mild cognitive impairment (MCI)-amnestic and multiple domain types-among nondemented and nondepressed elderly subjects aged 50 and older.
The study was carried out in Kolkata, the eastern metropolis of India. A cross-sectional community screening was carried out, and 960 subjects were selected by systematic random sampling for the assessment of cognitive function with the help of a validated cognitive questionnaire battery administered through house-to-house survey. A case-control study was also undertaken to identify potential risk factors through univariate analysis.
Ultimately, full evaluation of cognitive function was possible in 745 of 960 subjects. An overall prevalence of MCI detected based on neuropsychological testing was 14.89% (95% CI: 12.19 to 17.95). Prevalence of the amnestic type was 6.04% (95% CI: 4.40 to 8.1) and that of the multiple domain type was 8.85% (95% CI: 6.81 to 11.32). Adjusted for age, education. and gender, the amnestic type was more common among men and the multiple domain type among women with advancement of age. Rates differed considerably with educational attainment. Hypertension and diabetes mellitus were the major risk factors for both types of MCI.
In this first community-based study of mild cognitive impairment (MCI) from India, prevalence of the amnestic type is comparable with and that of the multiple domain type is less than the prevalence in developed countries. Variations in age, education, and gender specific prevalence of MCI of both types were encountered. The putative risk factors identified merit further study.
评估50岁及以上无痴呆和无抑郁的老年受试者中两种类型的轻度认知障碍（MCI）——遗忘型和多领域型——的患病率。
该研究在印度东部大都市加尔各答进行。开展了一项横断面社区筛查，通过系统随机抽样选取960名受试者，借助经验证的认知问卷组通过挨家挨户调查来评估认知功能。还进行了一项病例对照研究，通过单因素分析确定潜在风险因素。
最终，960名受试者中有745名得以进行全面的认知功能评估。基于神经心理学测试检测到的MCI总体患病率为14.89%（95%置信区间：12.19至17.95）。遗忘型的患病率为6.04%（95%置信区间：4.40至8.1），多领域型的患病率为8.85%（95%置信区间：6.81至11.32）。经年龄、教育程度和性别调整后，随着年龄增长，遗忘型在男性中更常见，多领域型在女性中更常见。患病率因教育程度不同而有很大差异。高血压和糖尿病是两种类型MCI的主要风险因素。
在印度这项首次基于社区的轻度认知障碍（MCI）研究中，遗忘型的患病率与发达国家相当，多领域型的患病率低于发达国家。两种类型的MCI在年龄、教育程度和性别特异性患病率方面存在差异。所确定的假定风险因素值得进一步研究。
