Banerjee T K, Mukherjee C S, Dutt A, Shekhar A, Hazra A
National Neurosciences Centre Calcutta, Kolkata, India.
Neuroepidemiology. 2008;31(2):109-14. doi: 10.1159/000146252. Epub 2008 Jul 21.
There is no prospective study of mild cognitive impairment (MCI) in India. This study aims to determine the prevalence rate of dementia and to prospectively analyze a group of patients with MCI. A door-to-door cross-sectional cluster survey was conducted in Kolkata, India, among those aged >50 years to estimate the prevalence rate of dementia. Then annual assessment of cognitive function using a validated questionnaire battery was undertaken among 21 elderly individuals with memory complaints for 4 consecutive years. A total of 53,907 persons were surveyed. The crude prevalence rates of dementia were 0.62% (95% CI 0.44-0.84) and 1.25% (95% CI 0.87-1.74) among those >50 and >60 years of age, respectively. The weighted prevalence rate among those above 50 years was 0.95% (95% CI 0.68-1.29). Alzheimer's disease was the commonest subtype (55%) followed by vascular dementia (36%). In a prospective study, MCI remained static, converted to dementia or reverted to normalcy. There was also transition from one subtype of MCI to another. A similar outcome of MCI is also noted in Western nations. However, the prevalence rate of dementia in Eastern India remained quite low.
印度尚无关于轻度认知障碍(MCI)的前瞻性研究。本研究旨在确定痴呆症的患病率,并对一组MCI患者进行前瞻性分析。在印度加尔各答,对年龄超过50岁的人群进行了挨家挨户的横断面整群调查,以估计痴呆症的患病率。然后,连续4年对21名有记忆问题主诉的老年人使用经过验证的问卷组进行认知功能年度评估。总共调查了53,907人。在年龄超过50岁和60岁的人群中,痴呆症的粗患病率分别为0.62%(95%CI 0.44 - 0.84)和1.25%(95%CI 0.87 - 1.74)。50岁以上人群的加权患病率为0.95%(95%CI 0.68 - 1.29)。阿尔茨海默病是最常见的亚型(55%),其次是血管性痴呆(36%)。在一项前瞻性研究中,MCI保持稳定、转变为痴呆症或恢复正常。也有从一种MCI亚型转变为另一种亚型的情况。在西方国家也观察到了类似的MCI结果。然而,印度东部痴呆症的患病率仍然相当低。