Kaplan Robert C, Ho Gloria Y F, Xue XiaoNan, Rajpathak Swapnil, Cushman Mary, Rohan Thomas E, Strickler Howard D, Scherer Philipp E, Anastos Kathryn
Department of Epidemiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1291-3. doi: 10.1158/1055-9965.EPI-06-1089.
Novel biomarkers including proinflammatory cytokines and adipokines are being explored as potential mediators of cancer and other obesity-related conditions. Prospective studies linking biomarker levels with disease outcomes often measure biomarkers at a single time point and assume that the within-individual variation in levels is small compared with the interindividual variation. However, this assumption is seldom tested.
This study examined the within-individual stability over time of plasma adiponectin, resistin, leptin, plasma activator inhibitor type 1, hepatocyte growth factor, tumor necrosis factor alpha, interleukin 6, and insulin among healthy young women.
The study included 17 women (9 Black non-Hispanic, 2 Black Hispanic, 2 White Hispanic, and 4 other race/ethnicity) with mean age of 32.3 years, mean body mass index of 31.2 kg/m2, and 76% prevalence of smoking. Analysis of intraclass correlation (ICC) suggested high to moderate correlation over repeated samples taken over 3 years in levels of resistin (ICC = 0.95), hepatocyte growth factor (0.91), plasma activator inhibitor type 1 (0.84), adiponectin (0.73), insulin (0.62), and leptin (0.58). ICCs were weaker for levels of proinflammatory cytokines, tumor necrosis factor alpha (0.39), and interleukin 6 (0.47).
In this population of minority young females with a high prevalence of overweight and smoking, several obesity-related endocrine markers were stable over a period of 3 years. This supports the feasibility of longitudinal studies relating these biomarkers to the future occurrence of cancer and other health consequences of obesity.
包括促炎细胞因子和脂肪因子在内的新型生物标志物正被探索作为癌症和其他肥胖相关病症的潜在介质。将生物标志物水平与疾病结局联系起来的前瞻性研究通常在单个时间点测量生物标志物，并假设个体内水平的变化与个体间变化相比很小。然而，这一假设很少得到检验。
本研究调查了健康年轻女性血浆脂联素、抵抗素、瘦素、血浆1型纤溶酶原激活物抑制剂、肝细胞生长因子、肿瘤坏死因子α、白细胞介素6和胰岛素随时间的个体内稳定性。
该研究纳入了17名女性（9名非西班牙裔黑人、2名西班牙裔黑人、2名西班牙裔白人以及4名其他种族/族裔），平均年龄为32.3岁，平均体重指数为31.2kg/m²，吸烟率为76%。组内相关系数（ICC）分析表明，在3年期间采集的重复样本中，抵抗素水平（ICC = 0.95）、肝细胞生长因子（0.91）、血浆1型纤溶酶原激活物抑制剂（0.84）、脂联素（0.73）、胰岛素（0.62）和瘦素（0.58）呈现高到中度的相关性。促炎细胞因子肿瘤坏死因子α（0.39）和白细胞介素6（0.47）的ICC值较弱。
在这个超重和吸烟率高的少数族裔年轻女性群体中，几种肥胖相关的内分泌标志物在3年期间是稳定的。这支持了将这些生物标志物与肥胖未来发生的癌症和其他健康后果相关联的纵向研究的可行性。
