Menzel J, Di Giuseppe R, Biemann R, Aleksandrova K, Kuxhaus O, Wittenbecher C, Fritsche A, Schulze M B, Isermann B, Boeing H, Weikert C
Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany.
Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Center, Berlin, Germany.
J Endocrinol Invest. 2016 Nov;39(11):1347-1355. doi: 10.1007/s40618-016-0544-3. Epub 2016 Sep 10.
Several studies implicated a crosstalk between bone and fat in the pathogenesis of osteoporosis. Few studies indicated an association between adiponectin and omentin-1 on the bone remodeling process and bone mineral density, and suggested osteoprotegerin (OPG) as a mediator of this relationship. However, only limited evidence on this relationship is available in humans. Therefore, this study aimed to investigate the association between omentin-1, adiponectin and broadband ultrasound attenuation (BUA) in peri-/premenopausal and postmenopausal women, and to assess the role of OPG as a possible mediator.
Data from the German population-based EPIC-Potsdam cohort comprising 637 women were analyzed. Multivariable-adjusted ANCOVA including age, BMI, waist circumference, smoking status, education, physical activity, adiponectin or omentin-1 and hormone use was used to investigate potential relationships between the adipokines and BUA levels. A mediation analysis assessed the mediating effect of OPG on the association of BUA and omentin-1 levels.
Peri-/premenopausal women had higher BUA levels (112.5 ± 10.1 dB/MHz), compared to postmenopausal women (106.3 ± 10.0 dB/MHz). In peri-/premenopausal women neither adiponectin nor omentin-1 was significantly associated with BUA. In postmenopausal women, adiponectin was not associated with BUA, but 10 % increase in the omentin-1 concentration was significantly associated with 0.44 dB/MHz lower BUA levels (p = 0.01). Omentin-1 was positively associated with OPG (p = 0.02); however, OPG was not significantly related to BUA (p = 0.62).
Our study provides evidence for an inverse association between circulating omentin-1 and BUA levels in postmenopausal women. However, the present findings do not support a mediating effect of OPG in the adipose tissue-bone pathway.
多项研究表明，在骨质疏松症的发病机制中，骨骼与脂肪之间存在相互作用。很少有研究指出脂联素和网膜素-1与骨重塑过程及骨密度之间存在关联，并认为骨保护素（OPG）是这种关系的介导因子。然而，关于这种关系，在人类中的证据有限。因此，本研究旨在调查围绝经期/绝经前及绝经后女性中网膜素-1、脂联素与宽带超声衰减（BUA）之间的关联，并评估OPG作为可能介导因子的作用。
分析了来自德国基于人群的EPIC-波茨坦队列的637名女性的数据。采用多变量调整的协方差分析，纳入年龄、体重指数、腰围、吸烟状况、教育程度、身体活动、脂联素或网膜素-1以及激素使用情况，以研究脂肪因子与BUA水平之间的潜在关系。中介分析评估了OPG对BUA与网膜素-1水平关联的中介作用。
围绝经期/绝经前女性的BUA水平（112.5±10.1dB/MHz）高于绝经后女性（106.3±10.0dB/MHz）。在围绝经期/绝经前女性中，脂联素和网膜素-1均与BUA无显著关联。在绝经后女性中，脂联素与BUA无关，但网膜素-1浓度增加10%与BUA水平降低0.44dB/MHz显著相关（p=0.01）。网膜素-1与OPG呈正相关（p=0.02）；然而，OPG与BUA无显著相关性（p=0.62）。
我们的研究为绝经后女性循环中网膜素-1与BUA水平之间的负相关提供了证据。然而，目前的研究结果不支持OPG在脂肪组织-骨骼途径中的中介作用。
