Sienaert Pascal, Peuskens Joseph
Electroconvulsive Therapy Department and Department of Mood Disorders, University Psychiatric Center-Katholieke Universiteit Leuven, Campus Kortenberg, Leuvensesteenweg, Kortenberg, Belgium.
J ECT. 2007 Jun;23(2):120-3. doi: 10.1097/YCT.0b013e3180330059.
To review the literature on the concurrent use of electroconvulsive therapy (ECT) and anticonvulsant drugs (AC) and to provide recommendations to guide clinical practice.
A MEDLINE search (1985-2006) was performed, using the terms "electroconvulsive therapy," "anticonvulsants," "epilepsy," "carbamazepine," "gabapentin," "lamotrigine," "topiramate," and "valproate," supplemented by manual searches of guidelines and textbooks on ECT.
To date, no prospective, randomized and controlled trials examining outcome and safety of the AC-ECT combination have been published. Existing data are from case reports on the use of ECT for psychiatric conditions that are simultaneously treated with AC, and from case reports of patients treated with ECT and AC for epilepsy or for psychiatric conditions with comorbid epilepsy. Apart from an occasional difficulty in eliciting seizures, no severe adverse effects or complications are reported.
The literature that is currently available indicates that ECT can be safely and effectively administered to patients treated with various AC. There is, however, no evidence to combine the 2 treatment modalities to augment therapeutic efficacy.
回顾关于电休克治疗（ECT）与抗惊厥药物（AC）联合使用的文献，并提供指导临床实践的建议。
进行了一次MEDLINE检索（1985 - 2006年），使用了“电休克治疗”“抗惊厥药”“癫痫”“卡马西平”“加巴喷丁”“拉莫三嗪”“托吡酯”和“丙戊酸盐”等检索词，并辅以对ECT指南和教科书的手工检索。
迄今为止，尚未发表过关于AC - ECT联合治疗的疗效和安全性的前瞻性、随机对照试验。现有数据来自关于ECT用于同时接受AC治疗的精神疾病的病例报告，以及ECT和AC用于癫痫或伴有癫痫的精神疾病患者的病例报告。除偶尔在诱发癫痫发作方面存在困难外，未报告严重不良反应或并发症。
目前可得的文献表明，ECT可安全有效地用于接受各种AC治疗的患者。然而，没有证据表明联合这两种治疗方式可提高治疗效果。
