Akhtar Asifa, Gasser Susan M
EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
Nat Rev Genet. 2007 Jul;8(7):507-17. doi: 10.1038/nrg2122. Epub 2007 Jun 5.
Cells have evolved sophisticated multi-protein complexes that can regulate gene activity at various steps of the transcription process. Recent advances highlight the role of nuclear positioning in the control of gene expression and have put nuclear envelope components at centre stage. On the inner face of the nuclear envelope, active genes localize to nuclear-pore structures whereas silent chromatin localizes to non-pore sites. Nuclear-pore components seem to not only recruit the RNA-processing and RNA-export machinery, but contribute a level of regulation that might enhance gene expression in a heritable manner.
细胞已经进化出复杂的多蛋白复合物，这些复合物可以在转录过程的各个步骤调节基因活性。最近的进展突出了核定位在基因表达控制中的作用，并使核膜成分成为核心焦点。在核膜的内表面，活跃基因定位于核孔结构，而沉默染色质定位于非孔部位。核孔成分似乎不仅能招募RNA加工和RNA输出机制，还能提供一种调节水平，可能以可遗传的方式增强基因表达。
