Stock Angus T, Mueller Scott N, Kleinert Lauren M, Heath William R, Carbone Francis R, Jones Claerwen M
Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia.
Immunol Cell Biol. 2007 Jul;85(5):394-6. doi: 10.1038/sj.icb.7100076. Epub 2007 Jun 5.
T-cell receptor (TCR) transgenic mice have proven useful for the study of various immune parameters. Despite this, it has been suggested that transferred T cells respond differently to their endogenous counterparts at least in terms of conversion to antigen-experienced populations bearing memory cell markers. Here, we have compared the response of TCR transgenic T cells to endogenous populations within the context of infection with herpes simplex virus. We found that adoptive transfer at numbers approaching those of the endogenous virus-specific subset results in a response with similar kinetics, magnitude and memory subset conversion. This suggests that this form of optimized T-cell transfer remains a useful means of tracking antiviral immune responses.
T细胞受体（TCR）转基因小鼠已被证明对研究各种免疫参数很有用。尽管如此，有人认为，转移的T细胞与其内源性对应物的反应不同，至少在转化为带有记忆细胞标记的抗原经验丰富群体方面是如此。在这里，我们比较了TCR转基因T细胞与单纯疱疹病毒感染背景下内源性群体的反应。我们发现，以接近内源性病毒特异性亚群数量的方式进行过继转移会导致具有相似动力学、幅度和记忆亚群转化的反应。这表明这种优化的T细胞转移形式仍然是追踪抗病毒免疫反应的有用手段。
