血管生物学与骨形成：低氧诱导因子的启示
Vascular biology and bone formation: hints from HIF.
作者信息
Towler Dwight A
机构信息
Department of Medicine, Center for Cardiovascular Research, Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
出版信息
J Clin Invest. 2007 Jun;117(6):1477-80. doi: 10.1172/JCI32518.
Abstract
In this issue of the JCI, Wang, Clemens, and colleagues demonstrate that hypoxia-inducible factor alpha (HIF alpha) signaling in bone-building osteoblasts is central to the coupling of angiogenesis and long bone development in mice (see the related article beginning on page 1616). They show that bone formation controlled by osteoblast HIF alpha signaling is not cell autonomous but is coupled to skeletal angiogenesis dependent upon VEGF signaling. Thus, strategies that promote HIF alpha signaling in osteoblasts may augment bone formation and accelerate fracture repair.
摘要
在本期《临床研究杂志》中，王、克莱门斯及其同事证明，在构建骨骼的成骨细胞中，缺氧诱导因子α（HIFα）信号传导对于小鼠血管生成与长骨发育的耦联至关重要（见第1616页开始的相关文章）。他们表明，由成骨细胞HIFα信号传导控制的骨形成并非细胞自主行为，而是与依赖VEGF信号传导的骨骼血管生成相耦联。因此，促进成骨细胞中HIFα信号传导的策略可能会增强骨形成并加速骨折修复。
相似文献
1
Vascular biology and bone formation: hints from HIF.血管生物学与骨形成：低氧诱导因子的启示
J Clin Invest. 2007 Jun;117(6):1477-80. doi: 10.1172/JCI32518.
2
The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development.在骨骼发育过程中，缺氧诱导因子α途径将血管生成与骨生成联系起来。
J Clin Invest. 2007 Jun;117(6):1616-26. doi: 10.1172/JCI31581.
3
Hypoxia-inducible factors 1alpha and 2alpha exert both distinct and overlapping functions in long bone development.缺氧诱导因子 1alpha 和 2alpha 在长骨发育中发挥着既独特又重叠的功能。
J Cell Biochem. 2010 Jan 1;109(1):196-204. doi: 10.1002/jcb.22396.
4
HIF-1 and HIF-2: working alone or together in hypoxia?缺氧诱导因子-1与缺氧诱导因子-2：在缺氧状态下单独作用还是协同作用？
J Clin Invest. 2007 Apr;117(4):862-5. doi: 10.1172/JCI31750.
5
Activated PAR-2 regulates pancreatic cancer progression through ILK/HIF-α-induced TGF-α expression and MEK/VEGF-A-mediated angiogenesis.激活的 PAR-2 通过 ILK/HIF-α 诱导的 TGF-α 表达和 MEK/VEGF-A 介导的血管生成来调节胰腺癌的进展。
Am J Pathol. 2013 Aug;183(2):566-75. doi: 10.1016/j.ajpath.2013.04.022. Epub 2013 Jun 10.
6
Salidroside accelerates fracture healing through cell-autonomous and non-autonomous effects on osteoblasts.红景天苷通过对成骨细胞的细胞自主和非自主作用加速骨折愈合。
Cell Tissue Res. 2017 Feb;367(2):197-211. doi: 10.1007/s00441-016-2535-2. Epub 2016 Dec 10.
7
Hypoxia, hypoxia-inducible transcription factors and oxygen-sensing prolyl hydroxylases in bone development and homeostasis.缺氧、缺氧诱导转录因子和氧感知脯氨酰羟化酶在骨骼发育和稳态中的作用。
Curr Opin Nephrol Hypertens. 2019 Jul;28(4):328-335. doi: 10.1097/MNH.0000000000000508.
8
Role of HIF-1alpha in skeletal development.HIF-1alpha 在骨骼发育中的作用。
Ann N Y Acad Sci. 2010 Mar;1192:322-6. doi: 10.1111/j.1749-6632.2009.05238.x.
9
Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related phosphatidylinositol 3-kinase/Akt and p38 mitogen-activated protein kinase pathways in osteoblasts.薯蓣皂苷元通过雌激素受体相关的磷脂酰肌醇3激酶/蛋白激酶B和p38丝裂原活化蛋白激酶途径诱导成骨细胞中缺氧诱导因子-1的激活和血管生成。
Mol Pharmacol. 2005 Oct;68(4):1061-73. doi: 10.1124/mol.104.010082. Epub 2005 Jul 5.
引用本文的文献
1
Knockdown of LncRNA H19 inhibits vascularization and endochondral ossification via the MiRNA-21a-5p-Smad7/p-Smad2/3 pathway in fracture repair.长链非编码RNA H19的敲低通过miRNA-21a-5p-Smad7/p-Smad2/3通路抑制骨折修复中的血管生成和软骨内成骨。
Sci Rep. 2025 Jul 18;15(1):26054. doi: 10.1038/s41598-025-11300-7.
2
Effect of Mesenchymal Stem Cells Overexpressing BMP-9 Primed with Hypoxia on BMP Targets, Osteoblast Differentiation and Bone Repair.缺氧预处理过表达BMP-9的间充质干细胞对BMP靶标、成骨细胞分化和骨修复的影响
Biology (Basel). 2023 Aug 19;12(8):1147. doi: 10.3390/biology12081147.
3
Clinical Potential of Mesenchymal Stem Cell-Derived Exosomes in Bone Regeneration.间充质干细胞来源外泌体在骨再生中的临床潜力
J Clin Med. 2023 Jun 29;12(13):4385. doi: 10.3390/jcm12134385.
4
Rare earth smart nanomaterials for bone tissue engineering and implantology: Advances, challenges, and prospects.用于骨组织工程与植入学的稀土智能纳米材料：进展、挑战与前景
Bioeng Transl Med. 2021 Dec 1;7(1):e10262. doi: 10.1002/btm2.10262. eCollection 2022 Jan.
5
Osteoblast Hypoxia-Inducible Factor-1α Pathway Activation Restrains Osteoclastogenesis the Interleukin-33-MicroRNA-34a-Notch1 Pathway.成骨细胞缺氧诱导因子-1α信号通路激活通过白细胞介素-33-微小RNA-34a-Notch1信号通路抑制破骨细胞生成。
Front Immunol. 2017 Oct 16;8:1312. doi: 10.3389/fimmu.2017.01312. eCollection 2017.
6
Porcine Bone Scaffolds Adsorb Growth Factors Secreted by MSCs and Improve Bone Tissue Repair.猪骨支架吸附间充质干细胞分泌的生长因子并促进骨组织修复。
Materials (Basel). 2017 Sep 8;10(9):1054. doi: 10.3390/ma10091054.
7
In vivo and in vitro characteristic of HIF-1α and relative genes in ischemic femoral head necrosis.缺血性股骨头坏死中HIF-1α及相关基因的体内和体外特性
Int J Clin Exp Pathol. 2015 Jun 1;8(6):7210-6. eCollection 2015.
8
Stimulating angiogenesis mitigates the unloading-induced reduction in osteogenesis in early-stage bone repair in rats.刺激血管生成可减轻大鼠早期骨修复中卸载诱导的成骨减少。
Physiol Rep. 2015 Mar;3(3). doi: 10.14814/phy2.12335.
9
HIF-1α change in serum and callus during fracture healing in ovariectomized mice.去卵巢小鼠骨折愈合过程中血清和骨痂中HIF-1α的变化
Int J Clin Exp Pathol. 2015 Jan 1;8(1):117-26. eCollection 2015.
10
Primary hypertrophic osteoarthropathy: an update.原发性肥大性骨关节病：更新。
Front Med. 2013 Mar;7(1):60-4. doi: 10.1007/s11684-013-0246-6. Epub 2013 Jan 23.
本文引用的文献
1
The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development.在骨骼发育过程中，缺氧诱导因子α途径将血管生成与骨生成联系起来。
J Clin Invest. 2007 Jun;117(6):1616-26. doi: 10.1172/JCI31581.
2
HIF-1 and HIF-2: working alone or together in hypoxia?缺氧诱导因子-1与缺氧诱导因子-2：在缺氧状态下单独作用还是协同作用？
J Clin Invest. 2007 Apr;117(4):862-5. doi: 10.1172/JCI31750.
3
Tumor necrosis factor-alpha receptor p75 is required in ischemia-induced neovascularization.肿瘤坏死因子-α受体p75在缺血诱导的新生血管形成中是必需的。
Circulation. 2007 Feb 13;115(6):752-62. doi: 10.1161/CIRCULATIONAHA.106.647255. Epub 2007 Jan 29.
4
Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis.Bmx/Etk在缺血介导的动脉生成和血管生成中的关键作用。
J Clin Invest. 2006 Sep;116(9):2344-55. doi: 10.1172/JCI28123. Epub 2006 Aug 24.
5
Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype.骨形态发生蛋白-2诱导促炎内皮细胞表型。
Am J Pathol. 2006 Feb;168(2):629-38. doi: 10.2353/ajpath.2006.050284.
6
Smooth muscle of the dorsal aorta shares a common clonal origin with skeletal muscle of the myotome.背主动脉的平滑肌与肌节的骨骼肌有着共同的克隆起源。
Development. 2006 Feb;133(4):737-49. doi: 10.1242/dev.02226.
7
In vitro modeling of paraxial and lateral mesoderm differentiation reveals early reversibility.体轴旁中胚层和侧中胚层分化的体外建模揭示了早期的可逆性。
Stem Cells. 2006 Mar;24(3):575-86. doi: 10.1634/stemcells.2005-0256. Epub 2005 Dec 9.
8
Circulating osteoblast-lineage cells in humans.人类循环中的成骨细胞系细胞。
N Engl J Med. 2005 May 12;352(19):1959-66. doi: 10.1056/NEJMoa044264.
9
Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals.Msx2 通过激活旁分泌 Wnt 信号促进心血管钙化。
J Clin Invest. 2005 May;115(5):1210-20. doi: 10.1172/JCI24140. Epub 2005 Apr 14.
10
Multiple roles of vascular endothelial growth factor (VEGF) in skeletal development, growth, and repair.血管内皮生长因子（VEGF）在骨骼发育、生长和修复中的多种作用。
Curr Top Dev Biol. 2005;65:169-87. doi: 10.1016/S0070-2153(04)65006-X.
Zotero 插件