Kafri Rachel, Shames Jeffrey, Raz Meir, Katz-Leurer Michal
Rehabilitation and Physical Therapy Centre, Maccabi Healthcare Services, Hasachlav 12, 75429, Rishon LeZion, Israel.
Int Urogynecol J Pelvic Floor Dysfunct. 2008 Jan;19(1):47-52. doi: 10.1007/s00192-007-0397-6. Epub 2007 Jun 5.
The objective of this study was to compare the residual effect of a 3-month rehabilitation treatment and a standard drug treatment for urge urinary incontinence (UUI) 21 months post intervention. Forty-four women (ages 27-68 years) who were diagnosed with overactive bladder (OAB) were divided into 2 treatment groups over 3 months: 24 women received rehabilitation (REH) and 20 women were treated with medication (MED) (oxybutynin ER). Outcomes measures included frequency of urination, quality of life (QoL), and number of side effects (no/SE), which were measured upon entry into the study (entry), completion of the intervention (3 months), and at follow-up 3 and 21 months after completion of treatment. In the follow-up period, there was a significant group-time interaction effect on freq/day and freq/night (p < 0.01). At the end of follow-up, the mean number of no/SE was significantly greater in the MED group compared to the REH group (3.3 +/- 0.5 vs 2.4 +/- 0.4; p < 0.05). A significant negative association was found between the urinary symptoms and the I-QoL at the 21-month follow-up (r (p) = -0.45 to-0.57, p < 0.05). In the long-term, the REH patients maintained and even improved the achievements of the intervention period while the MED patients deteriorated to baseline values in urinary frequency. The suggestion for future work is to investigate the effect of each REH treatment component on UUI symptoms.
本研究的目的是比较3个月康复治疗和标准药物治疗对尿急失禁（UUI）干预后21个月的残余效果。44名被诊断为膀胱过度活动症（OAB）的女性（年龄27 - 68岁）在3个月内被分为2个治疗组：24名女性接受康复治疗（REH），20名女性接受药物治疗（MED）（奥昔布宁缓释片）。结局指标包括排尿频率、生活质量（QoL）和副作用数量（无/有SE），这些指标在研究开始时（入组）、干预完成时（3个月）以及治疗完成后3个月和21个月的随访时进行测量。在随访期间，组间时间交互作用对每日排尿频率和夜间排尿频率有显著影响（p < 0.01）。随访结束时，MED组无/有SE的平均数量显著高于REH组（3.3 +/- 0.5 vs 2.4 +/- 0.4；p < 0.05）。在21个月随访时，发现泌尿症状与I-QoL之间存在显著的负相关（r（p）= -0.45至-0.57，p < 0.05）。从长期来看，REH组患者维持甚至改善了干预期的成果，而MED组患者的排尿频率恶化至基线值。对未来工作的建议是研究每种REH治疗成分对UUI症状的影响。
