Schwarting Gerald A, Henion Timothy R
Shriver Center and Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
J Neurosci Res. 2008 Jan;86(1):11-7. doi: 10.1002/jnr.21373.
The olfactory system represents a complex model for the investigation of factors that influence the guidance of sensory axon populations to specific targets in the CNS. In the mouse, the projections of approximately 1,000 neuronal subsets, each defined by expression of a distinct odorant receptor (OR), converge at unique glomerular loci in the olfactory bulb (OB). Unlike the case in other sensory systems, proper guidance is achieved without benefit of any known cues in the target itself that are capable of attracting or repelling specific axons. It has long been argued that OR proteins are the critical molecules orchestrating guidance. However, recent studies suggest that axon identity may be dependent on the graded expression of a variety of unique olfactory axon guidance cues. This review focuses attention on these non-OR factors and their roles in olfactory axon guidance.
嗅觉系统是一个复杂的模型，用于研究影响感觉轴突群体向中枢神经系统特定靶点导向的因素。在小鼠中，大约1000个神经元亚群的投射（每个亚群由独特的气味受体（OR）表达所定义）汇聚于嗅球（OB）中独特的肾小球位点。与其他感觉系统不同的是，在没有靶标自身任何已知的能够吸引或排斥特定轴突的线索的情况下，仍能实现正确的导向。长期以来，人们一直认为OR蛋白是协调导向的关键分子。然而，最近的研究表明轴突身份可能依赖于多种独特的嗅觉轴突导向线索的分级表达。本综述重点关注这些非OR因素及其在嗅觉轴突导向中的作用。
