Imai Takeshi, Sakano Hitoshi
Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0032, Japan.
Curr Opin Neurobiol. 2008 Jun;18(3):251-60. doi: 10.1016/j.conb.2008.07.009.
In the mouse olfactory system, there are approximately 1000 types of odorant receptors (ORs), which perform multiple functions in olfactory sensory neurons (OSNs). In addition to detecting odors, the functional OR protein ensures the singular gene choice of the OR by negative-feedback regulation. ORs also direct the axonal projection of OSNs both globally and locally by modulating the transcriptional levels of axon-guidance and axon-sorting molecules. In these latter processes, the second messenger, cAMP, plays differential roles in the fasciculation and targeting of axons. In this review, we will discuss how ORs differentially regulate intracellular signals for distinct functions.
在小鼠嗅觉系统中，大约有1000种气味受体（OR），它们在嗅觉感觉神经元（OSN）中发挥多种功能。除了检测气味外，功能性OR蛋白通过负反馈调节确保OR的单一基因选择。OR还通过调节轴突导向和轴突分选分子的转录水平，在全局和局部层面指导OSN的轴突投射。在这些后期过程中，第二信使环磷酸腺苷（cAMP）在轴突成束和靶向中发挥不同作用。在本综述中，我们将讨论OR如何针对不同功能差异调节细胞内信号。
