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运动诱发的左心室流出道梗阻。老年人症状的一个潜在原因。

Exercise-induced left ventricular outflow tract obstruction. A potential cause of symptoms in the elderly.

作者信息

Almeida Sofia, Cotrim Carlos, Brandão Luís, Miranda Rita, Loureiro Maria José, Simões Otília, Lopes Luís, Carrageta Manuel

机构信息

Serviço de Cardiologia do Hospital Garcia de Orta, Almada, Portugal.

出版信息

Rev Port Cardiol. 2007 Mar;26(3):257-62.

PMID:17549983
Abstract

We describe a 79-year-old male patient with no significant risk factors for coronary heart disease besides age and gender. He was referred for cardiology consultation because of effort dyspnea. Diagnostic exams including laboratory tests, chest X-ray, ECG and resting echocardiogram showed no abnormalities. He underwent exercise stress echocardiography, which revealed reduced exercise tolerance and a dynamic left ventricular outflow tract obstruction with an intraventricular gradient of over 50 mmHg. No segmental wall motion abnormalities were observed. He was treated with the beta-blocker bisoprolol 5 mg qd, with significant clinical improvement. Two years later exercise stress echocardiography was repeated and better functional capacity was apparent, with no intraventricular gradient during peak exercise. The authors discuss the clinical importance of this unsuspected cause of symptoms in the elderly.

摘要

我们描述了一位79岁男性患者,除年龄和性别外,无其他明显的冠心病危险因素。他因劳力性呼吸困难转诊至心内科咨询。包括实验室检查、胸部X线、心电图和静息超声心动图在内的诊断检查均未发现异常。他接受了运动负荷超声心动图检查,结果显示运动耐量降低,存在动态左心室流出道梗阻,室内压差超过50 mmHg。未观察到节段性室壁运动异常。给予他比索洛尔5 mg每日一次治疗,临床症状有显著改善。两年后重复进行运动负荷超声心动图检查,发现功能能力明显改善,运动高峰时无室内压差。作者讨论了这种在老年人中未被怀疑的症状原因的临床重要性。

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1
Exercise-induced left ventricular outflow tract obstruction. A potential cause of symptoms in the elderly.运动诱发的左心室流出道梗阻。老年人症状的一个潜在原因。
Rev Port Cardiol. 2007 Mar;26(3):257-62.
2
[Dynamic left ventricular outflow tract obstruction induced by exercise].[运动诱发的动态左心室流出道梗阻]
Rev Esp Cardiol. 2004 Dec;57(12):1179-87.
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Beta-blocker therapy for dynamic left ventricular outflow tract obstruction induced by exercise.
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Dynamic left ventricular outflow tract obstruction evoked by exercise echocardiography: prevalence and predictive factors in a prospective study.运动超声心动图诱发的动态左心室流出道梗阻:一项前瞻性研究中的患病率及预测因素
Eur J Echocardiogr. 2008 Sep;9(5):665-71. doi: 10.1093/ejechocard/jen070. Epub 2008 Apr 23.
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[Dynamic obstruction to left ventricular outflow during dobutamine stress echocardiography: the probable mechanisms and clinical implications].[多巴酚丁胺负荷超声心动图检查期间左心室流出道的动态梗阻:可能机制及临床意义]
Cardiologia. 1998 Nov;43(11):1201-8.
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Dynamic left ventricular obstruction evoked by exercise: importance of outflow tract size.运动诱发的动态左心室梗阻:流出道大小的重要性。
Eur J Echocardiogr. 2009 Jan;10(1):163; author reply 163-4. doi: 10.1093/ejechocard/jen293. Epub 2008 Oct 22.
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[Dobutamine stress causes left ventricular outflow tract obstruction].多巴酚丁胺负荷试验可导致左心室流出道梗阻
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Left ventricular outflow tract gradient decrease with non-surgical myocardial reduction improves exercise capacity in patients with hypertrophic obstructive cardiomyopathy.非手术心肌减容术使左心室流出道梯度降低,从而改善肥厚性梗阻性心肌病患者的运动能力。
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Exercise-induced intra-ventricular gradients as a frequent potential cause of myocardial ischemia in cardiac syndrome X patients.运动诱发的室内梯度作为心脏综合征X患者心肌缺血的常见潜在原因。
Cardiovasc Ultrasound. 2008 Jan 14;6:3. doi: 10.1186/1476-7120-6-3.
2
Clinical significance of intraventricular gradient during effort in an adolescent karate player.一名青少年空手道运动员运动时脑室内梯度的临床意义
Cardiovasc Ultrasound. 2007 Nov 19;5:39. doi: 10.1186/1476-7120-5-39.