波兰西部儿童甲状腺形态和功能因强化碘预防措施而发生的变化。
Changes in thyroid morphology and function in children in western Poland as a result of intensified iodine prophylaxis.
作者信息
Baczyk Maciej, Ruchała Marek, Pisarek Marlena, Pietz Leszek, Junik Roman, Sowiński Jerzy, Gembicki Maciej
机构信息
Department ofEndocrinology, Metabolism and Internal Diseases, Karol Marcinkowski University School of Medical Sciences, Poznań, Poland.
出版信息
J Pediatr Endocrinol Metab. 2007 Apr;20(4):511-5. doi: 10.1515/jpem.2007.20.4.511.
AIM
To determine the changes in thyroid pathology resulting from obligatory salt iodization in a group of children aged 8-12 years from the rural and urban areas of Wielkopolska Region, Poland.
POPULATION AND METHODS
The survey was conducted on 1215 children, of both sexes, 402 of whom were examined in 1992 (before salt iodization), 408 in 2000, and 405 in 2005 (after salt iodization beginning in 1996). Thyroid ultrasound, urinary iodine, FT4, FT3, TSH and antithyroid antibodies were measured.
RESULTS
A significant drop in goiter cases was observed (35.4% in 1992 vs 6.3% in 2005), coupled with a marked increase of urinary iodine. There were also changes in ultrasonography and elevated levels of antibodies.
CONCLUSIONS
The study proves the high efficacy of iodine prophylaxis. Despite a growing number of children with elevated antithyroid antibody titers, only a slight increase of autoimmune thyroid disorders was observed.
目的
确定波兰大波兰地区城乡8至12岁儿童群体中，强制食盐碘化对甲状腺病理状况的影响。
研究对象与方法
对1215名儿童进行了调查，其中402名儿童于1992年（食盐碘化之前）接受检查，408名于2000年接受检查，405名于2005年（1996年开始食盐碘化之后）接受检查。测量了甲状腺超声、尿碘、游离甲状腺素（FT4）、游离三碘甲状腺原氨酸（FT3）、促甲状腺激素（TSH）以及抗甲状腺抗体。
结果
观察到甲状腺肿病例显著减少（1992年为35.4%，2005年为6.3%），同时尿碘显著增加。超声检查也出现了变化，抗体水平升高。
结论
该研究证明了碘预防措施的高效性。尽管抗甲状腺抗体滴度升高的儿童数量不断增加，但仅观察到自身免疫性甲状腺疾病略有增加。
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