Teruya Jun, West Aaron G, Suell Mary Nell
Special Coagulation Laboratory, Texas Children's Hospital, Houston, TX, USA.
Arch Pathol Lab Med. 2007 Jun;131(6):885-9. doi: 10.5858/2007-131-885-LAAQAA.
Lupus anticoagulants are antibodies with heterogenous specificities to phospholipids. They have been associated with clinical syndromes consisting of thrombosis and recurrent fetal loss.
To address questions about the laboratory assay aspects of lupus anticoagulants. This review is intended for clinicians managing lupus anticoagulant testing in clinical laboratories.
Published literature on lupus anticoagulants, with emphasis on laboratory assay methods.
Although there are published criteria for confirming the presence of a lupus anticoagulant, there is no consensus on assay methods for lupus anticoagulant testing. The mixing study is a useful screening test for lupus anticoagulants, but it may have limited utility. Clinical context may necessitate the performance of factor assays in addition to lupus anticoagulant testing to rule out factor deficiency or factor-specific inhibitor. Additionally, the presence of different anticoagulants may affect the reliability of lupus anticoagulant assays. Lupus anticoagulants are an independent risk factor for thrombosis. It may be useful to use different assays when there is clinical suspicion for a lupus anticoagulant. When testing for lupus anticoagulants, clinicians must carefully consider the clinical context because factor assays may also be indicated.
狼疮抗凝物是一类对磷脂具有异质性特异性的抗体。它们与包括血栓形成和反复流产在内的临床综合征相关。
探讨狼疮抗凝物实验室检测方面的问题。本综述面向临床实验室中负责狼疮抗凝物检测管理的临床医生。
关于狼疮抗凝物的已发表文献，重点是实验室检测方法。
尽管已有确认狼疮抗凝物存在的标准，但狼疮抗凝物检测的方法尚无共识。混合试验是狼疮抗凝物的一种有用筛查试验，但效用可能有限。临床情况可能需要在进行狼疮抗凝物检测之外还进行因子检测，以排除因子缺乏或因子特异性抑制剂。此外，不同抗凝物的存在可能影响狼疮抗凝物检测的可靠性。狼疮抗凝物是血栓形成的独立危险因素。当临床怀疑存在狼疮抗凝物时，使用不同检测方法可能有用。在检测狼疮抗凝物时，临床医生必须仔细考虑临床情况，因为也可能需要进行因子检测。
