Rahemtullah Aliyah, Van Cott Elizabeth M
Coagulation Laboratory, Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA.
Arch Pathol Lab Med. 2007 Jun;131(6):890-901. doi: 10.5858/2007-131-890-HTIIS.
The utility of laboratory testing for hypercoagulability in the setting of stroke is uncertain.
To review the current literature and to make recommendations with regard to laboratory testing for various hypercoagulability risk factors for ischemic stroke.
Published articles studying the utility of various hypercoagulation tests in predicting initial and/or recurrent stroke or transient ischemic attack as well as cerebral vein thrombosis were collected and reviewed, with an emphasis on prospective studies.
Certain tests, such as C-reactive protein, homocysteine, antiphospholipid antibodies, and lipoprotein(a), may be useful in patients with a history of stroke or at high risk for stroke, as evidenced by prospective data. Factor V Leiden, prothrombin G20210A, protein C, protein S, and antithrombin are not recommended for routine testing but may be useful in certain populations, such as in pediatric patients or in patients with cerebral vein thrombosis.
在中风情况下，实验室检测对高凝状态的效用尚不确定。
回顾当前文献，并就缺血性中风各种高凝风险因素的实验室检测提出建议。
收集并回顾了已发表的研究各种高凝检测在预测初次和/或复发性中风、短暂性脑缺血发作以及脑静脉血栓形成中的效用的文章，重点是前瞻性研究。
前瞻性数据表明，某些检测，如C反应蛋白、同型半胱氨酸、抗磷脂抗体和脂蛋白(a)，可能对有中风病史或中风高危患者有用。不建议对因子V莱顿突变、凝血酶原G20210A、蛋白C、蛋白S和抗凝血酶进行常规检测，但在某些人群中可能有用，如儿科患者或脑静脉血栓形成患者。
