Cho Eun Yoon, Kim Kyoung-Mee, Park Cheol Keun, Kim Jae J, Sohn Tae Sung, Kim Duk Whan
Department of Pathology, Samsung Biomedical Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
APMIS. 2007 Jun;115(6):713-8. doi: 10.1111/j.1600-0463.2007.apm_639.x.
Alpha-methylacyl-CoA racemase (AMACR) is a novel tumor biomarker expressed in a number of neoplasms, including colorectal and prostatic adenocarcinomas. However, AMACR expression has not been investigated in preneoplastic and neoplastic lesions of the stomach. Using immunohistochemistry we studied the expression of AMACR in normal gastric mucosa (n=32), intestinal metaplasia (n=26), adenomas (n=29) and adenocarcinomas (n=132) of the stomach from 135 patients. Synchronous adenocarcinomas arising in the background of adenomas were observed in 26 cases. AMACR immunoreactivity was not observed in all normal gastric mucosa. Tissue from intestinal metaplasia, adenomas, and adenocarcinomas was positive in 7.7% (2/26), 79.3% (23/29), and 62.9% (83/132) of cases, respectively. The difference in AMACR expression between adenomas or adenocarcinomas and non-neoplastic mucosa was statistically significant (p=0.0001). Moreover, intestinal-type carcinomas showed significantly higher expression of AMACR (69.8%) compared to diffuse-type carcinomas (47.2%) (p=0.02). Our results indicate that as well as being an additional diagnostic tool, altered AMACR expression in gastric adenomas and intestinal-type carcinomas suggests that AMACR may be involved early in the development of intestinal-type gastric carcinomas.
α-甲基酰基辅酶A消旋酶（AMACR）是一种新型肿瘤生物标志物，在包括结直肠癌和前列腺腺癌在内的多种肿瘤中表达。然而，尚未对胃的癌前病变和肿瘤性病变中的AMACR表达进行研究。我们采用免疫组织化学方法，研究了135例患者胃的正常胃黏膜（n = 32）、肠化生（n = 26）、腺瘤（n = 29）和腺癌（n = 132）中AMACR的表达情况。在26例病例中观察到腺瘤背景下发生的同步腺癌。并非所有正常胃黏膜中都观察到AMACR免疫反应性。肠化生、腺瘤和腺癌组织的阳性率分别为7.7%（2/26）、79.3%（23/29）和62.9%（83/132）。腺瘤或腺癌与非肿瘤性黏膜之间AMACR表达的差异具有统计学意义（p = 0.0001）。此外，肠型癌中AMACR的表达（69.8%）明显高于弥漫型癌（47.2%）（p = 0.02）。我们的结果表明，AMACR不仅是一种额外的诊断工具，胃腺瘤和肠型癌中AMACR表达的改变提示其可能在肠型胃癌的早期发展中起作用。
