Comunoğlu Nil Ustündagğ, Durak Haydar, Comunoğlu Cem, Ekici A Işin Doğan, Ozkan Ferda, Akyildiz Elif Ulker, Ilvan Sennur, Calay Zerrin, Molinas Nil
Department of Pathology, Yeditepe University School of Medicine, Kayişdaği, Turkey.
APMIS. 2007 Jun;115(6):726-35. doi: 10.1111/j.1600-0463.2007.apm_629.x.
We examined the expression pattern of cyclooxygenase-2 (COX-2) and c-kit in uterine smooth muscle neoplasms and tried to determine the role of these markers in differential diagnosis. Archival tissue from 64 patients with uterine smooth muscle neoplasms (20 leiomyomas (LMs), 22 atypical leiomyomas (ALMs), and 22 leiomyosarcomas (LMSs)) was immunostained with antibodies against estrogen (ER) and progesterone receptors (PR), COX-2 and c-kit. 7 of 20 LM cases and 5 of 22 ALM cases were immunopositive for COX-2, whereas none of the LMS cases stained immunopositive (p< or =0.05). 4 of 20 LM cases and 5 of 22 ALM cases were immunopositive for c-kit, whereas 15 of 22 LMS cases showed c-kit immunopositivity (p< or =0.05). In conclusion, very few LMs and ALMs show COX-2 immunopositivity. LMSs usually do not express COX-2. COX-2 expression in smooth muscle tumors is not a prominent feature. Therefore, COX-2 inhibitors may not be useful in LMS therapy. C-kit was significantly expressed in uterine LMSs.
我们检测了环氧化酶-2（COX-2）和c-kit在子宫平滑肌肿瘤中的表达模式，并试图确定这些标志物在鉴别诊断中的作用。对64例子宫平滑肌肿瘤患者（20例平滑肌瘤（LM）、22例非典型平滑肌瘤（ALM）和22例平滑肌肉瘤（LMS））的存档组织进行雌激素（ER）和孕激素受体（PR）、COX-2和c-kit抗体免疫染色。20例LM病例中有7例、22例ALM病例中有5例COX-2免疫阳性，而LMS病例中无一例免疫染色阳性（p≤0.05）。20例LM病例中有4例、22例ALM病例中有5例c-kit免疫阳性，而22例LMS病例中有15例显示c-kit免疫阳性（p≤0.05）。总之，极少LM和ALM显示COX-2免疫阳性。LMS通常不表达COX-2。COX-2在平滑肌肿瘤中的表达不是一个突出特征。因此，COX-2抑制剂可能对LMS治疗无效。c-kit在子宫LMS中显著表达。
